Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride manufacturers
- MnTBAP chloride
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- $55.00
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2026-08-26
- CAS:55266-18-7
- Purity: 98.00%
- Supply Ability: 10g
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| | Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Basic information |
| Product Name: | Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride | | Synonyms: | Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride;Manganese(III) meso-tetra(4-carboxyphenyl)porphine chloride;Mn(III)TBAP (chloride);5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin-Mn(III) chloride (MnTBAP);5,10,15,20-Tetrakis(4-carboxyphenyl)-21H,23H-porphine]manganese(III) chloride;MnTBAP chloride, Superoxide dismutase (SOD) mimetic;MnTBAP chloride, 10 mM in DMSO | | CAS: | 55266-18-7 | | MF: | C48H28ClMnN4O8 | | MW: | 879.148969 | | EINECS: | | | Product Categories: | | | Mol File: | 55266-18-7.mol |  |
| | Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Chemical Properties |
| storage temp. | -20C | | solubility | Soluble in 0.1M NaOH | | form | Brown solid | | color | Black | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month. | | InChIKey | XHVDAQLNUQLQKW-PTJHDCLZSA-K | | SMILES | [Mn]1([n]2c3c(c5nc(c(c7[n]1c(c(c9nc(c(c2cc3)c%10ccc(cc%10)C(=O)O)cc9)c8ccc(cc8)C(=O)O)cc7)c6ccc(cc6)C(=O)O)cc5)c4ccc(cc4)C(=O)O)Cl |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Usage And Synthesis |
| Description | MnTBAP (55266-18-7) is a superoxide dismutase (SOD) mimetic. Potent peroxynitrite scavenger but does not scavenge nitric oxide. | | Uses | MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite scavenger. | | General Description | Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 μM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO). | | Biochem/physiol Actions | Cell permeable: yes | | in vivo | MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1]. | Animal Model: | C57BL/6J mice with 5/6 nephrectomy (Nx)[1] | | Dosage: | 10mg/kg | | Administration: | IP; three times per week for twelve weeks | | Result: | Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
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| | IC 50 | NFκB | | References | [1] CSABA SZABÓ Andrew L S Brian J Day. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger[J]. FEBS Letters, 1996, 381 1-2: 82-86. DOI:10.1016/0014-5793(96)00087-7
[2] K M FAULKNER I F S I Liochev. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.[J]. The Journal of Biological Chemistry, 1994, 269 38: 23471-23476. |
| | Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Preparation Products And Raw materials |
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