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2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE

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Products Intro: Product Name:KB-R7943 mesylate
CAS:182004-65-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:kb-r7943 mesylate
CAS:182004-65-5
Purity:0.99 Package:1kg
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Products Intro: Product Name:2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
CAS:182004-65-5
Purity:99% Package:1KG;1USD
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Products Intro: Product Name:KB-R7943 mesylate
CAS:182004-65-5
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Products Intro: Product Name:2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
CAS:182004-65-5
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE manufacturers

  • KB-R7943 mesylate
  • KB-R7943 mesylate pictures
  • 2025-04-04
  • CAS:182004-65-5
  • Min. Order: 1kg
  • Purity: 98%
  • Supply Ability: 1Ton
2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Basic information
Product Name:2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
Synonyms:Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester methanesulfonate;Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester monomethanesulfonate;KB-R7943;2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE;2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate;4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate
CAS:182004-65-5
MF:C17H21N3O6S2
MW:427.49
EINECS:
Product Categories:Signalling;Ion transporter and other ion channel
Mol File:182004-65-5.mol
2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Structure
2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Chemical Properties
Melting point >214°C (dec.)
storage temp. Inert atmosphere,2-8°C
solubility Soluble in DMSO (up to 50 mg/ml).
form White crystalline solid
color Tan
Water Solubility water: 4mg/mL
DMSO: 40mg/mL
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIInChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChIKeyWGIKEBHIKKWJLG-UHFFFAOYSA-N
SMILESS(O)(=O)(=O)C.C(C1C=CC(N(=O)=O)=CC=1)OC1C=CC(CCSC(N)=N)=CC=1
Safety Information
WGK Germany WGK 3
HS Code 2930.90.2900
Storage Class11 - Combustible Solids
MSDS Information
2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Usage And Synthesis
DescriptionKB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50‘s = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) Ki = 5.5 μM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM) and block NMDA receptors (IC50 = 13.4 μM).4
UsesKB-R7943 Mesylate is a selective inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.
General DescriptionA cell-permeable inhibitor of the influx/reverse mode of the Na+/Ca2+ exchanger (NCX) (IC50 = 4.3 μM for NCX1, 4.7 μM for NCX2, and 1.4 μM for NCX3). Directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported ot offer neuronal and cardio-protection against ischemic injury. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50<10 μM).
Biological ActivityPotent, selective inhibitor of the reverse mode of the Na + /Ca 2+ exchanger (IC 50 = 0.7 mM). Does not affect Na + -dependent transport systems, Na + channels or ionotropic glutamate receptors.
Biochem/physiol ActionsTarget IC50: 4.3 μM, 4.7 μM, and 1.4 μM for NCX1,NCX2, and NCX3, respectively
storageRoom temperature
References[1] T IWAMOTO  M S  T Watano. A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.[J]. The Journal of Biological Chemistry, 1996, 271 37: 22391-22397. DOI:10.1074/jbc.271.37.22391
[2] K. HOYT. Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.[J]. Molecular Pharmacology, 1998, 53 4 1: 742-749. DOI:10.1124/mol.53.4.742
[3] J SANTO-DOMINGO. The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter[J]. British Journal of Pharmacology, 2009, 151 5: 647-654. DOI:10.1038/sj.bjp.0707260
[4] TATIANA BRUSTOVETSKY. KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I[J]. British Journal of Pharmacology, 2010, 162 1: 255-270. DOI:10.1111/j.1476-5381.2010.01054.x
2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Preparation Products And Raw materials
Tag:2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE(182004-65-5) Related Product Information
BAPTA-AM Vanoxerine dihydrochloride SKF 96365 HYDROCHLORIDE IONOMYCIN SULFURYL FLUORIDE Salvia polyphenolate IMINOCTADINE TRIS(ALBESILATE) 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE