- ZM 336372
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- $34.00
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2026-04-20
- CAS:208260-29-1
- Purity: 97.51%
- Supply Ability: 10g
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| | ZM 336372 Basic information |
| | ZM 336372 Chemical Properties |
| Boiling point | 484.4±45.0 °C(Predicted) | | density | 1.298 | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO: >5mg/mL (warmed) | | pka | 8.31±0.15(Predicted) | | form | powder | | color | white to beige | | Sensitive | Light Sensitive | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | InChI | 1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28) | | InChIKey | PYEFPDQFAZNXLI-UHFFFAOYSA-N | | SMILES | N(C)(C)c1cc(ccc1)C(=O)Nc2cc(c(cc2)C)NC(=O)c3ccc(cc3)O |
| WGK Germany | 3 | | HS Code | 2924297099 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Chronic 4
Skin Sens. 1B |
| | ZM 336372 Usage And Synthesis |
| Description | The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation. | | Uses | It is small molecule tyrosine kinase modulator. ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines. | | Definition | ChEBI: 3-(dimethylamino)-N-[3-[[(4-hydroxyphenyl)-oxomethyl]amino]-4-methylphenyl]benzamide is a member of benzamides. | | IC 50 | c-Raf: 0.07 μM (IC50, 0.1 mM ATP) | | References | [1] C A HALL-JACKSON. Paradoxical activation of Raf by a novel Raf inhibitor.[J]. Chemistry & biology, 1999, 6 8: 559-568. DOI:10.1016/s1074-5521(99)80088-x
[2] DUSTIN DEMING M.D. . ZM336372 Induces Apoptosis Associated with Phosphorylation of GSK-3β in Pancreatic Adenocarcinoma Cell Lines[J]. Journal of Surgical Research, 2010, 161 1: Pages 28-32. DOI:10.1016/j.jss.2009.06.013 |
| | ZM 336372 Preparation Products And Raw materials |
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