4'-Chlorodiazepam

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4'-Chlorodiazepam Basic information
Product Name:4'-Chlorodiazepam
Synonyms:7-Chloro-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one;2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-;Aids080743;Aids-080743;7-chloro-1,3-dihydro-1-methyl-5-(p-chlorophenyl)-2h-1,4-benzodiazepin-2-one;7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one;7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one;7-CHLORO-5-(4-CHLOROPHENYL)-1,3-DIHYDRO-1-METHYL-2H-1,4-BENZODIAZEPIN-2-ONE
CAS:14439-61-3
MF:C16H12Cl2N2O
MW:319.19
EINECS:
Product Categories:
Mol File:14439-61-3.mol
4'-Chlorodiazepam Structure
4'-Chlorodiazepam Chemical Properties
Melting point 160-163 °C
Boiling point 517.1±50.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility ethanol: 17 mg/mL
form Off-white powder
pka3.08±0.10(Predicted)
color White to light yellow
Water Solubility 2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
BRN 685202
InChI1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
InChIKeyPUMYFTJOWAJIKF-UHFFFAOYSA-N
SMILESO=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 22-24/25
RIDADR 2811
WGK Germany 3
RTECS DF0500000
F 10
HazardClass 6.1(b)
PackingGroup III
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Hazardous Substances Data14439-61-3(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
4'-Chlorodiazepam Usage And Synthesis
Uses4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines.
Biochem/physiol Actions4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.
4'-Chlorodiazepam Preparation Products And Raw materials
Tag:4'-Chlorodiazepam(14439-61-3) Related Product Information
4'-Chlorodiazepam [N-methyl-3H] 1-Methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 4-Chloro-N-methylformanilide 4'-Chlorodiazepam 4-Chloro-2-methylacetanilide 4-Chloro-o-toluidine hydrochloride N-Me-Gly-NMe2 4-Chloro-N,N-dimethylaniline Benzhydrylidene methylamine Diazapam Nordazepam Benzophenone imine CHEMBRDG-BB 5668895 MEDAZEPAM 1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one