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| | Neuromedin B (trifluoroacetate salt) Basic information |
| | Neuromedin B (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Neuromedin B (trifluoroacetate salt) Usage And Synthesis |
| Description | Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor). It displays similar affinity for frog [Phe13]bombesin receptors (Ki = 11 nM) and lower affinities for human gastrin-releasing peptide receptor and bombesin receptor subtype 3 (Kis = 440 and 4,800 nM, respectively). Intrathecal administration of NMB (0.1-1 nmol) induces dose-dependent itching behavior in mice. NMB (50 μg, s.c.) reduces serum thyroid stimulating hormone (TSH) by 30% in mice indicating a role in pituitary-thyroid axis function. In rodents, NMB is also involved in mediating stress and fear responses, thermoregulation, and can stimulate the contraction of the uterus and gastrointestinal smooth muscle. | | References | [1] R R RYAN. Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 290 3: 1202-1211.
[2] DEVKI D SUKHTANKAR Mei C K. Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.[J]. PLoS ONE, 2013: e67422. DOI: 10.1371/journal.pone.0067422
[3] K J OLIVEIRA. Disruption of neuromedin B receptor gene results in dysregulation of the pituitary-thyroid axis.[J]. Journal of molecular endocrinology, 2006, 36 1: 73-80. DOI: 10.1677/jme.1.01892
[4] NIEVES GONZALEZ. Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states.[J]. Current Opinion in Endocrinology & Diabetes and Obesity, 2008, 15 1: 58-64. DOI: 10.1097/med.0b013e3282f3709b |
| | Neuromedin B (trifluoroacetate salt) Preparation Products And Raw materials |
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