| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
|
| | GnRH II (trifluoroacetate salt) Basic information |
| | GnRH II (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | GnRH II (trifluoroacetate salt) Usage And Synthesis |
| Description | Gonadotropin-releasing hormone II (GnRH II) is a peptide agonist of the GnRH receptor (GnRHR).1 It binds to human recombinant type I and marmoset type II GnRHRs (IC50s = 26.1 and 1.07 nM, respectively, in COS-7 cells) and stimulates inositol phosphate production (EC50s = 7.41 and 0.45 nM, respectively). GnRH II stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from cultured primary rhesus monkey anterior pituitary cells (EC50s = 0.37 and 0.59 nM, respectively) and dose-dependently stimulates LH and FSH release from cultured primary rat anterior pituitary cells.2 In vivo, GnRH II (1 μg/kg, i.v.) increases plasma LH levels in White Leghorn pullets but does not affect plasma FSH levels.3 It also decreases food intake in zebrafish and increases courtship behavior in female white-crowned sparrows when administered intracerebroventricularly at doses of 1 pmol/g and 100 ng, respectively.4,5WARNING This product is not for human or veterinary use. | | References | [1] R MILLAR. A novel mammalian receptor for the evolutionarily conserved type II GnRH.[J]. Open Economies Review, 2001, 30 1: 9636-9641. DOI: 10.1073/pnas.141048498
[2] YOHEI OKADA. Evidence that gonadotropin-releasing hormone (GnRH) II stimulates luteinizing hormone and follicle-stimulating hormone secretion from monkey pituitary cultures by activating the GnRH I receptor.[J]. Biology of Reproduction, 2003, 69 4: 1356-1361. DOI: 10.1095/biolreprod.103.016162
[3] JOHN A. PROUDMAN . Comparison of the ability of the three endogenous GnRHs to stimulate release of follicle-stimulating hormone and luteinizing hormone in chickens[J]. Domestic animal endocrinology, 2006, 31 2: Pages 141-153. DOI: 10.1016/j.domaniend.2005.10.002
[4] RYO NISHIGUCHI. Gonadotropin-releasing hormone 2 suppresses food intake in the zebrafish, Danio rerio.[J]. Frontiers in Endocrinology, 2012, 3: 122. DOI: 10.3389/fendo.2012.00122
[5] DONNA L. MANEY John C W Ralph D Richardson. Central Administration of Chicken Gonadotropin-Releasing Hormone-II Enhances Courtship Behavior in a Female Sparrow[J]. Hormones and Behavior, 1997, 32 1: Pages 11-18. DOI: 10.1006/hbeh.1997.1399 |
| | GnRH II (trifluoroacetate salt) Preparation Products And Raw materials |
|