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| | Arginine Vasotocin (trifluoroacetate salt) Basic information |
| | Arginine Vasotocin (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Arginine Vasotocin (trifluoroacetate salt) Usage And Synthesis |
| Description | Arginine vasotocin is a nonapeptide hormone agonist of the AVT receptor (EC50 = 13 nM for eliciting membrane currents in X. laevis oocytes). Arginine vasotocin is synthesized in the pineal recess and subcommissural organ by ependymal cells and released into the cerebrospinal fluid. It inhibits the induction of sleep and release of hypothalamic releasing and inhibiting hormones. Arginine vasotocin stimulates glycogen phosphorylase α activity and incorporation of phosphate into phosphatidylinositol in rat hepatocytes (EC50s = 0.5 nM and 6.3 nM, respectively). Following a two-minute pulse of arginine vasotocin (1 μM) to neurons isolated from rat suprachiasmatic nuclei, 40.6% of neurons show an increase in firing rate with 11% of the activated neurons responding only to arginine vasotocin and not argipressin . Arginine vasotocin (0.1 μg, i.c.v.) activates sexual behavior in male newts and increases the number of clasps per male from saline control levels of 0.6 to 2.9 in an eight-hour period. In rainbow trout, arginine vasotocin (0.1 ng/g, i.c.v.) reduces food intake by over 95% and, after eight hours, increases cortisol and glucose levels by 89% and 27%, respectively. | | References | [1] S MAHLMANN. Structure, function, and phylogeny of [Arg8]vasotocin receptors from teleost fish and toad.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 4: 1342-1345. DOI: 10.1073/pnas.91.4.1342
[2] PAVEL S. Arginine vasotocin as a pineal hormone.[J]. Journal of Neural Transmission-supplement, 1978, 13: 135-155.
[3] C J KIRK;D A H;L M Rodrigues. The influence of vasopressin and related peptides on glycogen phosphorylase activity and phosphatidylinositol metabolism in hepatocytes.[J]. Biochemical Journal, 1979, 178 2: 493-496. DOI: 10.1042/bj1780493
[4] R. MIHAI . The effects of [arg8]vasopressin and [ARG8]vasotocin on the firing rate of suprachiasmatic neuronsin vitro[J]. Neuroscience, 1994, 62 3: Pages 783-792. DOI: 10.1016/0306-4522(94)90476-6
[5] FRANK L. MOORE;Larry J M. Arginine vasotocin induces sexual behavior of newts by acting on cells in the brain[J]. Peptides, 1983, 4 1: Pages 97-102. DOI: 10.1016/0196-9781(83)90173-0
[6] M. GESTO. Arginine Vasotocin Treatment Induces a Stress Response and Exerts a Potent Anorexigenic Effect in Rainbow Trout, Oncorhynchus mykiss[J]. Journal of Neuroendocrinology, 2013, 26 2: 89-99. DOI: 10.1111/jne.12126 |
| | Arginine Vasotocin (trifluoroacetate salt) Preparation Products And Raw materials |
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