- UCB9608
-
- $50.00
-
2026-07-14
- CAS:1616413-96-7
- Purity: 98.65%
- Supply Ability: 10g
|
| | UCB9608 Basic information |
| Product Name: | UCB9608 | | Synonyms: | UCB9608;6-amino-4-{4-[(4-methoxy-2-methylphenyl)carbamyl]-2-(S)-methylpiperazin-1-yl}-1-methylpyrazolo[3,4-d]pyrimidine;CS-2884;UCB 9608;UCB9608;1-Piperazinecarboxamide, 4-(6-amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methyl-, (3S)-;(3S)-4-(6-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methyl-1-piperazinecarboxamide;Phosphatidylinositol 4 kinases,UCB-9608,Inhibitor,UCB 9608,UCB9608,PI4 kinases,PI4K,inhibit;(S)-4-(6-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamide | | CAS: | 1616413-96-7 | | MF: | C20H26N8O2 | | MW: | 410.47 | | EINECS: | | | Product Categories: | | | Mol File: | 1616413-96-7.mol |  |
| | UCB9608 Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 13.36±0.70(Predicted) | | color | White to off-white | | InChIKey | WRONAJQPZWDYAR-ZDUSSCGKSA-N | | SMILES | N1(C(NC2=CC=C(OC)C=C2C)=O)CCN(C2N=C(N)N=C3N(C)N=CC3=2)[C@@H](C)C1 |
| | UCB9608 Usage And Synthesis |
| Uses | UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent[1]. | | References | [1] Reuberson J, et al. Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem. 2018 Aug 9;61(15):6705-6723. DOI:10.1021/acs.jmedchem.8b00521 |
| | UCB9608 Preparation Products And Raw materials |
|