| Company Name: |
ChemShuttle, Inc. |
| Tel: |
0510-83588313-811 18800520310 |
| Email: |
sales@chemshuttle.com |
UCB-9260 manufacturers
- UCB-9260
-
- $98.00
-
2026-07-27
- CAS:1515888-53-5
- Purity: 99.24%
- Supply Ability: 10g
- UCB-9260
-
- $98.00
-
2026-07-27
- CAS:1515888-53-5
- Purity: 99.24%
- Supply Ability: 10g
|
| | UCB-9260 Basic information |
| Product Name: | UCB-9260 | | Synonyms: | UCB-9260;(1-(2,5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol;cytotoxicity,asymmetric,trimer,Inhibitor,neutrophil,autoimmune,Tumor Necrosis Factor Receptor,UCB-9260,TNFR,rheumatoid,arthritis,inhibit,UCB 9260,TNF Receptor,cytokine,selective,UCB9260;1H-Benzimidazole-2-methanol, 1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-α-4-pyridinyl-;UCB-9260, 10 mM in DMSO;UCB-9260 ，S3231;1-[(2,5-Dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-α-4-pyridinyl-1H-benzimidazole-2-methanol | | CAS: | 1515888-53-5 | | MF: | C26H25N5O | | MW: | 423.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1515888-53-5.mol |  |
| | UCB-9260 Chemical Properties |
| Boiling point | 722.0±60.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (295.15 mM; Need ultrasonic) | | pka | 11.97±0.20(Predicted) | | form | Solid | | color | Brown to gray |
| | UCB-9260 Usage And Synthesis |
| Uses | UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer.UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similarKdof 13nM[1]. | | in vivo | UCB-9260 (150mg/kg; p.o.;twice dailyfor 7 days) shows a significant reduction of the clinical score[1].
UCB-9260(10-300mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice[1]. | Animal Model: | Aged 6-8 weeks adult male Balb/c mice(CAIA model)[1] | | Dosage: | 150mg/kg | | Administration: | p.o.; twice daily for 7days | | Result: | Showed a significant reduction of the clinical score. |
| | References | [1] O'Connell J, et al.SmallmoleculesthatinhibitTNFsignallingbystabilisinganasymmetricformof thetrimer.Nat Commun.2019 Dec 19;10(1):5795. DOI:10.1038/s41467-019-13616-1 |
| | UCB-9260 Preparation Products And Raw materials |
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