|
|
| | Z-Pro-Pro-aldehyde-dimethyl acetal Basic information |
| Product Name: | Z-Pro-Pro-aldehyde-dimethyl acetal | | Synonyms: | 1-Pyrrolidinecarboxylic acid, 2-[[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl]-, phenylmethyl ester, (2S)-;Z-Pro-Pro-aldehyde-dimethyl acetal | | CAS: | 170116-63-9 | | MF: | C20H28N2O5 | | MW: | 376.45 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | Z-Pro-Pro-aldehyde-dimethyl acetal Chemical Properties |
| Boiling point | 522.5±50.0 °C(Predicted) | | density | 1.214±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | pka | -1.00±0.40(Predicted) | | Sequence | Pro-{Pro-Aldehyde-dimethyl acetal} |
| | Z-Pro-Pro-aldehyde-dimethyl acetal Usage And Synthesis |
| Uses | Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2]. | | IC 50 | PREP: 12 nM (IC50) | | References | [1] Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. DOI:10.1038/417292a
[2] Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglialandTHP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. DOI:10.1002/glia.20645 |
| | Z-Pro-Pro-aldehyde-dimethyl acetal Preparation Products And Raw materials |
|