RS 102895

RS 102895 Suppliers list

Company Name:	Shanghai UCHEM Inc.
Tel:	+862156762820 +86-13564624040
Email:	sales@myuchem.com
Products Intro:	Product Name:RS 102895 CAS:300815-41-2 Purity:0.98 Package:5G;1G

Company Name:	Hefei Hirisun Pharmatech Co., Ltd
Tel:	+8615056975894
Email:	shawn@hirisunpharm.com
Products Intro:	Product Name:RS 102895 hydrochloride CAS:300815-41-2 Purity:0.98 Package:1G;5G;25G;Bulk for inquiry Remarks:HR110054

Company Name:	Henan Aochuang Chemical Co.,Ltd.
Tel:	+86-0371-63689365 +8618638391208
Email:	sales@aochuangchem.com
Products Intro:	Product Name:RS 102895 CAS:300815-41-2 Purity:98% Package:1kg;USD\|10kg;USD\|25kg;USD

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354;
Email:	support@targetmol.com
Products Intro:	Product Name:RS102895 CAS:300815-41-2 Purity:99.54% Package:5mg;59USD\|10mg;97USD\|25mg;178USD

Company Name:	Zibo Hangyu Biotechnology Development Co., Ltd
Tel:	+86-0533-2185556 +8615965530500
Email:	nickzhang@hangyubiotech.com
Products Intro:	Product Name:RS 102895 CAS:300815-41-2

RS 102895 manufacturers

RS 102895 Basic information

Product Name:	RS 102895
Synonyms:	1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-;1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895;RS102895, 10 mM in DMSO
CAS:	300815-41-2
MF:	C21H21F3N2O2
MW:	390.4
EINECS:
Product Categories:	RS 102895 CCR2-selective chemokine receptor antagonist.;Cytokine signaling
Mol File:	300815-41-2.mol

RS 102895 Chemical Properties

Boiling point	446.1±45.0 °C(Predicted)
density	1.33±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	Desiccate at RT
solubility	DMSO: 18 mg/mL, clear, colorless
form	powder
pka	13.46±0.20(Predicted)
color	white
InChI	1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
InChIKey	KRRISOFSWVKYBF-UHFFFAOYSA-N
SMILES	Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1

Safety Information

MSDS Information

RS 102895 Usage And Synthesis

Uses	RS 102895 is a CCR2-selective chemokine receptor inhibitor.
Biological Activity	CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.
in vivo	RS102895 (3 g/L) causes progressive decrease in pain threshold in rats with bone cancer pain (BCP) at day 3-9 after surgery via intrathecal injection, but the pain threshold increases after 12 days. RS102895 also potently reverses the pattern of NR2B, nNOS, and SIGIRR expression in spinal cord^[3].
IC 50	CCR2: 360 nM (IC₅₀); CCR1: 17800 nM (IC₅₀); Human α_1a receptor: 130 nM (IC₅₀); Human α_1d receptor: 320 nM (IC₅₀); 5HT-1a receptor: 470 nM (IC₅₀)

RS 102895 Preparation Products And Raw materials

Tag:RS 102895(300815-41-2) Related Product Information

2,3-Dichloro-5-(trifluoromethyl)pyridine 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride Inter-trifluoromethyl iodobenzene 4-(2-AMINOPHENYL)-1-PHENETHYLPIPERIDINE 4-(O-AMINO-PHENYL) PIPERIDINE HYDROCHLORIDE RS 102895 1-Phenethyl-4-phenyl-4-piperidinol SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE