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6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9& manufacturers
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| | 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9& Basic information |
| Product Name: | 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9& | | Synonyms: | 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9&;1,2,3,4-Tetrahydro-6-chlorocarbazole;NSC 298291;6-CHLORO-1,2,3,4-TETRAHYDROCARBAZOLE, 98 %;6-Chloro-1,2,3,4-tetrahydrocarbazole >;1H-Carbazole, 6-chloro-2,3,4,9-tetrahydro- | | CAS: | 36684-65-8 | | MF: | C12H12ClN | | MW: | 205.68 | | EINECS: | | | Product Categories: | Building Blocks;Carbazoles;CarbazolesHeterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks | | Mol File: | 36684-65-8.mol |  |
| | 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9& Chemical Properties |
| Melting point | 145-148 °C (lit.) | | Boiling point | 358.8±37.0 °C(Predicted) | | density | 1.280 | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | slightly sol. in Methanol | | pka | 16.93±0.20(Predicted) | | form | powder to crystal | | color | White to Light yellow | | λmax | 292nm(ethylene glycol)(lit.) | | InChI | InChI=1S/C12H12ClN/c13-8-5-6-12-10(7-8)9-3-1-2-4-11(9)14-12/h5-7,14H,1-4H2 | | InChIKey | CNQQPGJXOHSTQR-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C(Cl)C=C2)C2=C1CCCC2 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2933.99.8290 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9& Usage And Synthesis |
| Synthesis | GENERAL METHODS: Cyclohexanone (0.91 g, 10.0 mmol) was mixed with bis(trifluoromethanesulfonyl)imide salt ([(HSO3-p)2im][CF3SO3]) (0.5 mmol) in deionized water (15 mL), followed by the addition of p-chlorophenylhydrazine hydrochloride (1.44 g, 10.0 mmol). The reaction mixture was placed in a microwave reactor and stirred at 100 °C for about 15 min, and the reaction process was monitored by gas chromatography-mass spectrometry (GC-MS). After completion of the reaction, the mixture was cooled to room temperature and the precipitate was collected by filtration to afford 6-chloro-1,2,3,4-tetrahydrocarbazole. The mixed system of [(HSO3-p)2im][CF3SO3]/H2O used in the reaction can be directly recycled for subsequent reactions. | | References | [1] Journal of Fluorine Chemistry, 2012, vol. 144, p. 45 - 50,6
[2] Tetrahedron Letters, 2018, vol. 59, # 22, p. 2145 - 2149
[3] Heterocyclic Communications, 2003, vol. 9, # 1, p. 9 - 12
[4] Organic and Biomolecular Chemistry, 2016, vol. 14, # 41, p. 9868 - 9873
[5] Patent: CN105968039, 2016, A. Location in patent: Paragraph 0049-0051 |
| | 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9& Preparation Products And Raw materials |
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