| Company Name: |
Shanghai UCHEM Inc. |
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+86-18930848214 +86-021-56762820 |
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sales@myuchem.com |
YDL223C manufacturers
- YDL223C
-
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2026-09-20
- CAS:489408-02-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 2000
- YDL223C
-
- $3.00
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2026-08-25
- CAS:489408-02-8
- Purity: 99%
- YDL223C
-
-
2026-08-25
- CAS:489408-02-8
- Min. Order: 1KG
- Purity: 0.99
- Supply Ability: 1000KG
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| | YDL223C Basic information |
| Product Name: | YDL223C | | Synonyms: | YDL223C;1H-Pyrazole-1-acetamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-methyl-3-(trifluoromethyl)-;2-(2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide;HBT1
Synonyms:YDL223C;HBT 1,Ionotropic glutamate receptors,HBT-1,BDNF,LBD,inhibit,glutamate,AMPA,primary neurons,S518,HBT1,iGluR,AMPA-R,Inhibitor;HBT1, 10 mM in DMSO | | CAS: | 489408-02-8 | | MF: | C16H17F3N4O2S | | MW: | 386.39 | | EINECS: | 206-141-6 | | Product Categories: | HBT1 | | Mol File: | 489408-02-8.mol |  |
| | YDL223C Chemical Properties |
| Boiling point | 531.9±50.0 °C(Predicted) | | density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | form | Solid | | pka | 11.28±0.20(Predicted) | | color | White to off-white | | InChI | 1S/C16H17F3N4O2S/c1-8-6-11(16(17,18)19)22-23(8)7-12(24)21-15-13(14(20)25)9-4-2-3-5-10(9)26-15/h6H,2-5,7H2,1H3,(H2,20,25)(H,21,24) | | InChIKey | PHLXSNIEQIKENK-UHFFFAOYSA-N | | SMILES | O=C(N)C1=C(NC(CN2C(C)=CC(C(F)(F)F)=N2)=O)SC3=C1CCCC3 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | YDL223C Usage And Synthesis |
| Description | Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, YNL195C, that arose from the whole genome duplication. | | Uses | HBT1 is a potent α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiator. HBT1 bonds with S518 in the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. HBT1 did not show remarkable bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons[1]. | | Biochem/physiol Actions | HBT1(YDL223C) is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner. | | References | [1] Akiyoshi Kunugi, et al. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. DOI:10.1124/jpet.117.245050 |
| | YDL223C Preparation Products And Raw materials |
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