FEN1 Inhibitor C2
| 中文名称 | FEN1 Inhibitor C2 |
|---|---|
| 中文同义词 | 1-(环丙基甲基)-3-羟基喹唑啉-2,4(1H,3H)-二酮;化合物FEN1 INHIBITOR C2;化合物FEN1 INHIBITOR C2,10 MM DMSO 溶液;FEN1-IN-4 试剂;FEN1-IN-4 ,S3397;FEN1-IN-4 试剂;FEN1-IN-4【CAS:1995893-58-7】【规格:5mg】【纯度:99%】;FEN1-IN-4【CAS：1995893-58-7】【规格：5mg】【纯度：99%】 |
| 英文名称 | FEN1 Inhibitor C2 |
| 英文同义词 | FEN1 Inhibitor C2;FEN1-IN-4;2,4(1H,3H)-Quinazolinedione, 1-(cyclopropylmethyl)-3-hydroxy-;1-(Cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione;flap,colorectal,Inhibitor,endonuclease,FEN1IN4,cells,colon,cancer,inhibit,FEN-1-IN-4,glioblastoma,FEN1 IN 4,human,hFEN1;FEN1-IN-4, 10 mM in DMSO;FEN1-IN-4 ，S3397 |
| CAS号 | 1995893-58-7 |
| 分子式 | C12H12N2O3 |
| 分子量 | 232.24 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1995893-58-7.mol |
| 结构式 |  |
FEN1 Inhibitor C2 性质
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：125 mg/mL（538.24 mM） |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
FEN1-IN-4 (Compound 2) 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。
hFEN1
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-136485 | FEN1-IN-4 | 1995893-58-7 | 1 mg | 419元 |
| 2026/09/15 | HY-136485 | FEN1 Inhibitor C2 FEN1-IN-4 | 1995893-58-7 | 5mg | 1000元 |