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| | Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-[[3-(2-propyn-1-yloxy)phenyl]methyl]-2-thiazolyl]- Basic information |
| | Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-[[3-(2-propyn-1-yloxy)phenyl]methyl]-2-thiazolyl]- Chemical Properties |
| density | 1.34±0.1 g/cm3(Predicted) | | pka | 7.94±0.50(Predicted) | | form | Solid | | color | White to yellow |
| | Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-[[3-(2-propyn-1-yloxy)phenyl]methyl]-2-thiazolyl]- Usage And Synthesis |
| Uses | SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1]. SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | References | [1] Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491. DOI:10.1021/acs.jmedchem.6b01872 |
| | Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-[[3-(2-propyn-1-yloxy)phenyl]methyl]-2-thiazolyl]- Preparation Products And Raw materials |
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