N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide

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N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide manufacturers

  • SirReal-1
  • SirReal-1 pictures
  • $2500.00
  • 2026-05-11
  • CAS:801227-82-7
  • Purity:
  • Supply Ability: 10g
N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide Basic information
Product Name:N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide
Synonyms:N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide;Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(phenylmethyl)-2-thiazolyl]-
CAS:801227-82-7
MF:C18H18N4OS2
MW:370.49
EINECS:
Product Categories:
Mol File:801227-82-7.mol
N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide Structure
N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide Chemical Properties
density 1.33±0.1 g/cm3(Predicted)
pka8.01±0.50(Predicted)
Safety Information
MSDS Information
N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide Usage And Synthesis
UsesSirReal-1 is a potent and selective Sirt2 inhibitor（IC50 = 3.7 uM）[1].
IC 50SIRT2: 3.7 μM (IC50)
References[1] Schiedel M, Rumpf T, Karaman B, et al. Structure-Based Development of an Affinity Probe for Sirtuin2. Angew Chem Int Ed Engl. 2016;55(6):2252-2256. DOI:10.1002/anie.201509843
[2] Rumpf T, Schiedel M, Karaman B, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.Nat Commun. 2015;6:6263. DOI:10.1038/ncomms7263
N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide Preparation Products And Raw materials
Tag:N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide(801227-82-7) Related Product Information
SirReal2 Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-[[3-(2-propyn-1-yloxy)phenyl]methyl]-2-thiazolyl]- N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide SirReal2 Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) gamma-Glu-Cys trifluoroacetate salt