5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine Suppliers list

Company Name:	ShangHai Movin Pharmaceutical Co., Ltd. Gold
Tel:	13681854265
Email:	info@moenpharm.com

Company Name:	JinYan Chemicals(ShangHai) Co.,Ltd.
Tel:	13817811078
Email:	sales@jingyan-chemical.com

Company Name:	Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel:	+86-21-54098501
Email:	sales@sinch.com.cn

5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine manufacturers

5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine Basic information

Product Name:	5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
Synonyms:	5-BROMO-2,3-DIHYDRO-7-AZAINDOLE;BROMO-2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE;3-dihydro-1H-pyrrolo[2;5-broMo-2;5-broMo-1H,2H,3H-pyrrolo[2,3-b]pyridine;5-Bromo-7-azaindoline;1H-Pyrrolo[2,3-b]pyridine, 5-bromo-2,3-dihydro-;5-Bromo-2,3-dihydro-7-azaindole 95%
CAS:	115170-40-6
MF:	C7H7BrN2
MW:	199.05
EINECS:	634-550-3
Product Categories:	CHIRAL CHEMICALS;Non-Chiral heterocyclic compounds;Heterocycle-Pyridine series;Amines and Anilines;Heterocycles
Mol File:	115170-40-6.mol

5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine Chemical Properties

Melting point	186-191 (Decomposition)
Boiling point	315.8±42.0 °C(Predicted)
density	1.606
Fp	136℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	solid
pka	9.31±0.20(Predicted)
color	Brown
InChI	1S/C7H7BrN2/c8-6-3-5-1-2-9-7(5)10-4-6/h3-4H,1-2H2,(H,9,10)
InChIKey	UZGNFPCHQUHZAI-UHFFFAOYSA-N
SMILES	Brc1cnc2NCCc2c1

Safety Information

MSDS Information

5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine Usage And Synthesis

Uses	5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine is a useful intermediate for organic synthesis.
Synthesis	10592-27-5 115170-40-6 a) 16.8 g (0.14 mol) of 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, 24.13 g (0.143 mol) of 48% hydrobromic acid and 260 g of methylene chloride were added to a reaction flask and stirred thoroughly to obtain reaction mixture C; b) The temperature of reaction mixture C was controlled at 25~30°C, and 20.20 g of 20% hydrogen peroxide solution was added slowly dropwise. hydrogen peroxide solution to obtain mixture D; c) Neutralize mixture D using 60 g of saturated aqueous sodium bisulfite solution until the red color of the reaction solution completely disappeared, and carry out partitioning to obtain the organic phase E and the aqueous phase F; d) Wash the organic phase E with 200 g of water; e) Recover the dichloromethane solvent from the organic phase E obtained in step d) to obtain 26.6 g of 5-bromo-2,3-dihydro-1H-pyrrolo[ 2,3-b]pyridine in 95.6% yield and the product was ≥99% pure by liquid chromatography.
References	[1] Patent: CN107987076, 2018, A. Location in patent: Paragraph 0048-0053; 0064-0069; 0074; 0080-0085 [2] Patent: CN105461718, 2016, A. Location in patent: Paragraph 0016 [3] Patent: WO2004/78757, 2004, A2. Location in patent: Page 48; 50-51 [4] Patent: WO2015/157504, 2015, A1. Location in patent: Page/Page column 37 [5] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 63

5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials

Raw materials	1,2,4-Triazin-3-amine, N-3-butyn-1-yl--->2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-->7-Azaindole-->Hydrogen peroxide-->Dichloromethane-->Hydrogen bromide
Preparation Products	tert-Butyl 5-broMo-2H,3H-pyrrolo[2,3-b]pyridine-1-carboxylate-->5-Bromo-7-azaindole

Tag:5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine(115170-40-6) Related Product Information

1H-Pyrrolo[3,2-b]pyridine, 5-broMo-2,3-dihydro- 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine 5-Bromo-1H-pyrrolo[2 , 3-b]pyridin-2(3H)-one 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine 5-Bromo-7-azaindole 7-Azaindole BUTTPARK 154\50-17 2-Amino-5-bromo-3-methylpyridine Pyridine, 3-bromo-5-ethyl- (9CI)