MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH

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MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH manufacturers
MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH Basic information
Product Name:MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH
Synonyms:MCA-ASP-GLU-VAL-ASP-ALA-PRO-LYS(DNP);MCA-DEVDAPK (DNP);MCA-DEVDAPK(DNP)-OH;CASPASE-3 SUBSTRATE III, FLUOROGENIC;CASPASE-3 SUBSTRATE (MCA);7-METHOXYCOUMARIN-4-ACETYL-ASP-GLU-VAL-ASP-ALA-PRO-(2,4-DINITROPHENYL)-LYS;7-methoxycoumarin-4-acetyl-asp-glu-*val-asp-ala-P;7-METHOXYCOUMARIN-4-ACETYL-ASP-GLU-*VAL- ASP-ALA-PRO
CAS:189696-20-6
MF:C50H62N10O22
MW:1155.08
EINECS:
Product Categories:Caspase 3;Caspase 3Caspase Inhibitors and Substrates;Caspase Substrates;Caspases;Substrates
Mol File:189696-20-6.mol
MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH Structure
MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH Chemical Properties
Boiling point 1561.2±65.0 °C(Predicted)
density 1.455±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility Formic Acid: 1 mg/ml
form Lyophilized powder
pka3.67±0.21(Predicted)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH Usage And Synthesis
Description

Mca-DEVDAPK(Dnp)-OH is a fluorogenic substrate for caspase-3. It is cleaved by caspase-3 to release the fluorescent moiety 7-methoxycoumarin-4-acetyl (Mca), which can be used to quantify caspase-3 activity.

UsesMca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3[1].
IC 50Caspase-3
References[1] Fertig Georg. Method for the detection of the apoptosis activated cysteine protease Caspase 3 by specific antibody-binding and fluorescence enzyme assay. EP0955377A1
SequeneMca-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH
MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH Preparation Products And Raw materials
Tag:MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH(189696-20-6) Related Product Information
MCA-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH N-(2,4-Dinitrophenyl)-6-aminohexanoic acid Ac-DEVD-CHO CHEMBRDG-BB 7932577 Mca-LEVDGW-K(Dnp)-NH2 (trifluoroacetate salt) Mca-RPPGFSAFK(Dnp)-OH (trifluoroacetate salt)