- Ac-DEVD-CHO acetate
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- $70.00 / 1mg
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2026-04-13
- CAS:
- Min. Order:
- Purity: 98.54%
- Supply Ability: 10g
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| | AC-DEVD-CHO Basic information |
| | AC-DEVD-CHO Chemical Properties |
| Boiling point | 1021.1±65.0 °C(Predicted) | | density | 1.374±0.06 g/cm3(Predicted) | | RTECS | EK7643000 | | storage temp. | -20°C | | solubility | H2O: 1 mg/mL | | pka | 4.19±0.10(Predicted) | | form | powder | | color | white | | biological source | synthetic | | Water Solubility | H2O: 1mg/mL | | Sensitive | Moisture Sensitive | | Sequence | N-Acetyl-Asp-Glu-Val-Asp-al | | InChIKey | UMBVAPCONCILTL-UHFFFAOYSA-N | | SMILES | [H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | AC-DEVD-CHO Usage And Synthesis |
| Uses | Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase | | Uses | N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells. | | Definition | ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde.
It is an inhibitor of caspase-3/7. | | General Description | N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation. | | Biochem/physiol Actions | N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality. | | in vivo | Compare with model group, in CI group, the concentrations of serum BUN are decreased significantly at all time points after operation and those of Cr are decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 are decreased and those of IL-10 are elevated significantly at all time points. [TNF-α (μg/L) 6 hours: 436.2±64.2 vs. 653.6±8.9, 12 hours: 233.4±85.4 vs. 579.7±137.1, 24 hours: 151.0±90.3 vs. 551.0±119.8, IL-6 (μg/L) 6 hours: 1033.2±345.8 vs. 1 595.3±159.4, 12 hours: 366.3±68.3 vs. 1 330.7±249.8, 24 hours: 241.2±208.4 vs. 815.3±572.7, IL-10 (μg/L) 6 hours: 33.6±10.4 vs. 26.6±4.5, 12 hours: 37.2±5.0 vs. 24.5±4.3, 24 hours: 38.3±5.5 vs. 18.2±1.6, all P<0.05]; the renal cell apoptosis rates are decreased significantly at all time points: apoptosis rates 6 hours: (13.9±3.2)% vs. (18.3±1.4)%, 12 hours: (10.5±3.6)% vs. (15.9±3.5)%, 24 hours: (8.4±1.8)% vs.(12.5±2.1)%[5]. | | IC 50 | Caspase 3: 0.23 nM (Ki); Caspase-8: 0.92 nM (Ki); Caspase-7: 1.6 nM (Ki); Caspase-10: 12 nM (Ki); Caspase-1: 18 nM (Ki); Caspase-6: 31 nM (Ki); Caspase-9: 60 nM (Ki); Caspase-4: 132 nM (Ki); Caspase-5: 205 nM (Ki); Caspase-2: 1710 nM (Ki) |
| | AC-DEVD-CHO Preparation Products And Raw materials |
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