椭圆玫瑰树碱
| 中文名称 | 椭圆玫瑰树碱 |
|---|---|
| 中文同义词 | 5,11-二甲基-6H-吡啶并[4,3-B]咔唑;椭圆玫瑰树碱溶液;玫瑰树碱;椭圆玫瑰树碱;玫瑰树碱(甄准不供应);玫瑰树碱/椭圆玫瑰树碱;玫瑰树碱,10 MM DMSO 溶液;玫瑰树碱, 一种有效的抗肿瘤剂, 抑制 DNA拓扑异构酶II 活性 |
| 英文名称 | ELLIPTICINE |
| 英文同义词 | ELLIPTICINE;5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE;5,11-DIMETHYLPYRIDO[4.3:B]CARBAZOLE;5,11-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE;CCG 36483;CCG36483;CCG-36483;CCG-36483; CCG36483; CCG 36483; BRN-0221300; BRN0221300; BRN 0221300; DB-052047; K00071; LP00531; LS-133282; NSC 71795; NSC71795; NSC-71795; TCMDC-125546; VZ29809. ELLIPTECINE; ELLIPTICINE; ELLIPTISINE |
| CAS号 | 519-23-3 |
| 分子式 | C17H14N2 |
| 分子量 | 246.31 |
| EINECS号 | 208-264-0 |
| 相关类别 | 植物提取物;小分子抑制剂，天然产物;小分子抑制剂;抑制剂;对照品;Alkaloids;Indoles and derivatives;Antitumour;Inhibitors |
| Mol文件 | 519-23-3.mol |
| 结构式 |  |
椭圆玫瑰树碱 性质
| 熔点 | 316-318°C |
|---|---|
| 沸点 | 379.31°C (rough estimate) |
| 密度 | 1.257±0.06 g/cm3 (20 ºC 760 Torr) |
| 折射率 | 1.5794 (estimate) |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | 可溶于DMSO |
| 酸度系数(pKa) | 16.59±0.40(Predicted) |
| 形态 | 亮黄色固体 |
| 颜色 | 浅黄至黄色 |
| Merck | 13,3581 |
| InChI | 1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3 |
| InChIKey | CTSPAMFJBXKSOY-UHFFFAOYSA-N |
| SMILES | [nH]1c2c(c4c1cccc4)c(c3c(c2C)ccnc3)C |
| LogP | 4.800 |
| CAS 数据库 | 519-23-3(CAS DataBase Reference) |
|
Topoisomerase II
|
Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.
Ellipticine (NSC 71795) treatment results in Ellipticine (NSC 71795)-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b 5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b 5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).
安全信息
| 提供商 | 语言 |
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英文
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