|
|
| | 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile Basic information |
| Product Name: | 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile | | Synonyms: | 7-Azaindole-6-carbonitrile;1H-PYRROLO[2,3-B]PYRIDINE-6-CARBONITRILE;6-Cyano-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine-6-carbonitrile(9CI);PYRROLO[2,3-B]PYRIDINE-6-CARBONITRILE;1H-PYRROLO[2,3-B]PYRIDINE-6-CARBONITRILE ISO 9001：2015 REACH;6-CYANO-7-AZAINDOLE | | CAS: | 189882-33-5 | | MF: | C8H5N3 | | MW: | 143.15 | | EINECS: | 251-156-6 | | Product Categories: | Azaindoles;PYRIDINE | | Mol File: | 189882-33-5.mol | ![1H-pyrrolo[2,3-b]pyridine-6-carbonitrile Structure](CAS/GIF/189882-33-5.gif) |
| | 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile Chemical Properties |
| Melting point | 187.4 °C | | Boiling point | 463.9±28.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 6.56±0.40(Predicted) | | Appearance | Light yellow to brown Solid | | InChI | InChI=1S/C8H5N3/c9-5-7-2-1-6-3-4-10-8(6)11-7/h1-4H,(H,10,11) | | InChIKey | GAFBPZMOMITHLG-UHFFFAOYSA-N | | SMILES | C12NC=CC1=CC=C(C#N)N=2 |
| | 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile Usage And Synthesis |
| Description |
7-Azaindole, as a bioisostere of indole or purine, is widely used in drug development. Among them, 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile is a key intermediate for the synthesis of a class of selective cyclin-dependent kinase (CDK) 7 inhibitors. Among mammalian CDKs, CDK7 has a unique integrated kinase activity that helps regulate the cell cycle and gene transcription. 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile can be prepared using 7-azaindole-7-oxide as a raw material.
| | Chemical Properties | Class white powder |
| | 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile Preparation Products And Raw materials |
|