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Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
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| | ANTI-CASPASE-3 Basic information |
| Product Name: | ANTI-CASPASE-3 | | Synonyms: | MONOCLONAL ANTIBODY TO CASPASE-3 (HUMAN) (31A1067);Anti-Caspase 3 antibody produced in rabbit;Anti-Caspase 3, Active antibody produced in rabbit;Monoclonal Anti-Caspase 3 antibody produced in mouse;Anti-CASP3 antibody produced in rabbit;Monoclonal Anti-CASP3 antibody produced in mouse;CASPASE-3 (AB-2) MONOCLONAL ANTIBODY;CASPASE-3 (AB-3) MONOCLONAL ANTIBODY | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-CASPASE-3 Structure]() |
| | ANTI-CASPASE-3 Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder | | biological source | rabbit |
| WGK Germany | 3 | | Storage Class | 12 - Non Combustible Liquids |
| | ANTI-CASPASE-3 Usage And Synthesis |
| Uses | Anti-Caspase 3, Active antibody has been used:
- for western blotting of cytochrome c for caspase activation
- as primary antibody in immunofluorescence staining of embryos and postnatal mice cryosections
- in Western blot analysis of activated caspase 3
- as a primary antibody in immunodetection of rat brain sections
| | General Description | Caspase-3 (CASP3) belongs to the class of cysteine proteases. CASP3is an executioner caspase, which is cleaved and activated with the help of caspase-8 and caspase-9 initiator caspases. CASP3is mapped to human chromosome 4q35.1. | | Biochem/physiol Actions | Caspase 3 is one of the key effectors of apoptosis. It acts downstream of caspase 9 in the apoptotic pathway. During apoptosis, it gets activated by proteolytic cleavage into the 17-19 kDa (p17, p18) and 12 kDa (p12) active subunits. Any alteraion in CASP-3 in mice, causes premature lethality. It has also shown that the deletion of gene affects brain development resulting of hyperplasias and disorganized cell deployement. Clinically it is related to Huntington disease (HD). Caspase 3 brings about cell death by activating CAD (caspase activated DNAse I), an endonuclease that causes degradation of chromosomal DNA. |
| | ANTI-CASPASE-3 Preparation Products And Raw materials |
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