| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
- PD150606
-
- $30.00
-
2026-08-04
- CAS:179528-45-1
- Purity: 98.19%
- Supply Ability: 10g
|
| | 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid Basic information |
| | 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid Chemical Properties |
| Boiling point | 410.4±45.0 °C(Predicted) | | density | 1.901±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: >20mg/mL | | form | powder | | pka | 2.98±0.10(Predicted) | | color | yellowish | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | InChI | 1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5- | | InChIKey | DJCVSFWGKYHMKH-YVMONPNESA-N | | SMILES | OC(=O)\C(S)=C\c1ccc(I)cc1 |
| Hazard Codes | T | | Risk Statements | 25-37/38-41-43 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | WGK 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| | 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid Usage And Synthesis |
| Description | PD-150606 (179528-45-1) is a selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices.1 PD-150606 displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death.2 Some protective effects may be due to inhibition of MMP activity.3 | | Uses | PD 150606 is a novel mercaptoacrylate based compound and a potent inhibitor of Ca2+-dependent activation of calpain-1, a Ca2+-activated cytosolic cysteine protease. PD 150606 may potentially be developed as an anti-inflammatory agent. Neuroprotective product. | | Definition | ChEBI: An organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer). | | Biochem/physiol Actions | PD 150606 is a selective; cell-permeable; non-peptide; uncompetitive calpain inhibitor. | | storage | Store at -20°C | | References | [1] K K WANG. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 13: 6687-6692. DOI:10.1073/pnas.93.13.6687
[2] S L WATERS. Calpains mediate calcium and chloride influx during the late phase of cell injury.[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 283 3: 1177-1184.
[3] MOHAMMAD A.M. ALI . Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity[J]. Biochemical and biophysical research communications, 2012, 423 1: Pages 1-5. DOI:10.1016/j.bbrc.2012.05.005 |
| | 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid Preparation Products And Raw materials |
|