| | 2-Phenylethylamine hydrochloride Basic information |
| Product Name: | 2-Phenylethylamine hydrochloride | | Synonyms: | B-PHENYLETHYLAMINE HYDROCHLORIDE;B-PHENYLETHYLAMINE HCL;2-PhenylethylamineHydrochloride,99%;beta-PhenethylamineHCl;1-Amino-2-phenylethane hydrochloride;2-Phenethylamine hydrochloride;Benzeneethanamino hydrochloride;1-Phenyl-2-aminoethane hydrochloride | | CAS: | 156-28-5 | | MF: | C8H12ClN | | MW: | 157.64 | | EINECS: | 205-849-2 | | Product Categories: | Pharma material;156-28-5 | | Mol File: | 156-28-5.mol |  |
| | 2-Phenylethylamine hydrochloride Chemical Properties |
| Melting point | 220-222 °C(lit.) | | Boiling point | 217 °C | | Fp | 81 °C | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | Powder or Crystalline Powder | | color | White to off-white | | Merck | 14,6026 | | BRN | 3624163 | | InChI | InChI=1S/C8H11N.ClH/c9-7-6-8-4-2-1-3-5-8;/h1-5H,6-7,9H2;1H | | InChIKey | SKHIBNDAFWIOPB-UHFFFAOYSA-N | | SMILES | C1(CCN)=CC=CC=C1.Cl | | LogP | 1.458 (est) | | CAS DataBase Reference | 156-28-5(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Phenylethylammonium chloride(156-28-5) | | EPA Substance Registry System | Benzeneethanamine, hydrochloride (156-28-5) |
| Hazard Codes | Xn,Xi,C | | Risk Statements | 22-36/37/38-34 | | Safety Statements | 26-36-45-36/37/39 | | RIDADR | 2811 | | WGK Germany | 3 | | RTECS | SH7175000 | | TSCA | TSCA listed | | HazardClass | 6.1(b) | | PackingGroup | III | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | | Toxicity | eye-man 50 mg SEV AIMDAP 39,404,27 |
| | 2-Phenylethylamine hydrochloride Usage And Synthesis |
| Description | 2-Phenethylamine is a natural monoamine alkaloid that acts as neuromodulator in the central nervous system. It stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases as well as other enzymes. This product is intended for forensic and research applications. | | Chemical Properties | White to Light yellow powder to crystal. soluble in water, alcohol, ether. | | Uses | 2-Phenylethylamine hydrochloride is the hydrochloride salt form of 2-Phenylethylamine, which is an biogenic aromatic amine acting as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system. It is used to CNS stimulant. | | Preparation | In a nitrogen environment, add the aliphatic nitro derivatives (0.6 mmol), pinacol borane (3.6 mmol, 6.0 equiv), tetrahydrofuran (2 mL), triethylboron (5 mol%), and potassium tert-butoxide (5 mol %) into a 10 mL sealed tube and then place it in a 100 oil bath with heating and stirring for 24 hours. At the end of the reaction, add 2mL of 1M hydrochloric acid aqueous solution to the reaction solution and stir at room temperature for 6 h. Finally, 2-Phenylethylamine hydrochloride is obtained by filtration.
 | | Safety Profile | Poison by skin contact, subcutaneous, and intravenous routes. A human eye irritant. A skin irritant and possible sensitizer. Human systemic effects by ingestion: blood pressure lowering, anorexia. When heated to decomposition it emits very toxic fumes of | | References | [1] MASATO NAKAMURA Daiichiro N Akira Ishii. Characterization of β-phenylethylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study[J]. European journal of pharmacology, 1998, 349 2: Pages 163-169. DOI: 10.1016/s0014-2999(98)00191-5
[2] H Y YANG N H N. Beta-phenylethylamine: a specific substrate for type B monoamine oxidase of brain.[J]. Journal of Pharmacology and Experimental Therapeutics, 1973, 187 2: 365-371.
[3] O. SUZUKI M. O Y Katsumata. Oxidation of β-Phenylethylamine by Both Types of Monoamine Oxidase: Examination of Enzymes in Brain and Liver Mitochondria of Eight Species[J]. Journal of Neurochemistry, 1981, 36 3: 1298-1301. DOI: 10.1111/j.1471-4159.1981.tb01734.x |
| | 2-Phenylethylamine hydrochloride Preparation Products And Raw materials |
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