- 2-Fluoroisoniazide
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2025-04-04
- CAS:369-24-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- 2-Fluoroisoniazide
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- $1.00
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2020-02-01
- CAS:369-24-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200kgs
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| Product Name: | 2-Fluoroisoniazide | | Synonyms: | 2-Fluoroisoniazide;2-Fluoropyridine-4-carbohydrazide;2-fluoroisonicotinohydrazide;4-Pyridinecarboxylicacid, 2-fluoro-, hydrazide;2-FLUOROISONICOTINIC ACID HYDRAZIDE;2-fluoro-4-pyridinecarbohydrazide | | CAS: | 369-24-4 | | MF: | C6H6FN3O | | MW: | 155.13 | | EINECS: | | | Product Categories: | | | Mol File: | 369-24-4.mol |  |
| | 2-Fluoroisoniazide Chemical Properties |
| Melting point | 218-220 °C | | density | 1.356±0.06 g/cm3(Predicted) | | pka | 10.53±0.10(Predicted) |
| | 2-Fluoroisoniazide Usage And Synthesis |
| Application | 2-Fluoroisoniazid and para-aminosalicylic acid isoniazid have become alternative drugs, but the vast majority of doctors still consider 2-fluoroisoniazid an indispensable primary drug for the treatment of tuberculosis. It is considered a first-line anti-tuberculosis drug, along with rifampicin, ethambutol, streptomycin, and pyrazinamide. | | Synthesis | To 2000ml three-necked bottle add 1.62mol 2-fluoroisonicotinic acid, 1200g ethanol, 16.4g (0.162mol) triethylamine, stirring to lower the temperature to 0 C ~ 5 C, slowly drop 212g (1.78mol) sulfoxide chloride, dropletting is completed, controlled temperature 0 C ~ 5 C insulation for 2 hours, and then warmed up to 20 C ~ 25 C insulation for 20 hours, the reaction is complete, the Decompression concentration of the oil, will be 119g (2.43mol) hydrazine hydrate to add, warming to 70 ~ 75 , holding 10 hours, add diluent (water 350g), appropriate warming, dissolution, to get aqueous solution of 2-fluoroisonicotinic acid hydrazide crude, add 10g of activated charcoal, 70 ~ 75 holding time of half an hour, filtration, filtrate is naturally cooled for 6 hours, and then slowly cooled to 0 , filtration The filtrate was naturally cooled for 6 hours, then slowly cooled to 0C, filtered and dried to obtain the finished product of isoniazid with the purity of 99.94%, the single impurities were all less than 0.10%, the impurity J was not detected, and the total yield of 2-fluoroisonicotinic acid hydrazide was 86%. |
| | 2-Fluoroisoniazide Preparation Products And Raw materials |
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