3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Suppliers list

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3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine manufacturers

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Basic information

Product Name:	3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine
Synonyms:	3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE;3,4-Dihydro-2H-pyrido[3,2-b]oxazine;2H,3H,4H-pyrido[3,2-b][1,4]oxazine;2,3-dihydropyrido[3,2-b][1,4]oxazine;2H-Pyrido[3,2-b]-1,4-oxazine, 3,4-dihydro-;3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine ISO 9001：2015 REACH;Compound Fr16627
CAS:	20348-23-6
MF:	C7H8N2O
MW:	136.15
EINECS:
Product Categories:	Heterocyclic Series
Mol File:	20348-23-6.mol

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Chemical Properties

Safety Information

HazardClass	IRRITANT
HS Code	2933399990

MSDS Information

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Usage And Synthesis

Definition	ChEBI: 3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine is a secondary amine.
Synthesis	20348-09-8 20348-23-6 (a) Synthesis of 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine: To a solution of 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (5.00 g, 33.3 mmol) in tetrahydrofuran (THF, 40 mL) was slowly added lithium aluminium hydroxide (66.6 mL, 1.0 M THF solution. 66.6 mmol). After addition, the reaction mixture was heated to reflux. After 18 hours of reaction, the reaction was cooled to 0 °C and water (4 mL), sodium hydroxide solution (4 mL, 15%) and water (10 mL) were added sequentially to quench the reaction. Subsequently, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated to afford the target product 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine (3.87 g, 85% yield) as a blue-gray powder. The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 7.53 (dd, J=4.5,1.0 Hz, 1H), 6.90-6.89 (m, 1H), 6.61 (br s, 1H), 6.44 (dd, J=8.0,3.0 Hz, 1H), 4.08 (t, J=4.5 Hz, 2H), 3.39- 3.36 (m, 2H); mass spectrum (ESI) m/e 131 (M+H)+.
References	[1] Patent: WO2007/53131, 2007, A2. Location in patent: Page/Page column 133 [2] Patent: EP1226138, 2004, B1 [3] Acta Chemica Scandinavica (1947-1973), 1969, vol. 23, p. 2322 - 2324 [4] Patent: US2008/305169, 2008, A1 [5] Patent: US2007/10670, 2007, A1. Location in patent: Page/Page column 92

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Preparation Products And Raw materials

Raw materials

Tag:3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine(20348-23-6) Related Product Information

2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one 7-Chloro-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)one 2-(2-Hydroxyethyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one BUTTPARK 26\07-99 BUTTPARK 26\07-94 2-(3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-2-yl)ethyl 4-nitrobenzenecarboxylate 2-(3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-2-yl)ethyl 4-chlorobenzenecarboxylate 2-(3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-2-yl)ethyl 2-furoate 2-(3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-2-yl)ethyl 4-fluorobenzenecarboxylate 2-[2-(4-Ethylpiperazino)ethyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 2-[2-(4-Benzylpiperazino)ethyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one BUTTPARK 26\07-91 BUTTPARK 26\07-96 BUTTPARK 26\07-95 BUTTPARK 26\07-100 BUTTPARK 26\07-97 BUTTPARK 26\07-98 BUTTPARK 26\07-92