viquidil manufacturers
- Viquidil
-
- $1980.00 / 50mg
-
2026-01-04
- CAS:84-55-9
- Min. Order:
- Purity:
- Supply Ability: 10g
- Viquidil
-
- $1980.00 / 50mg
-
2025-07-20
- CAS:84-55-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | viquidil Basic information |
| Product Name: | viquidil | | Synonyms: | 1-(6-Methoxy-4-quinolyl)-3-[(3R,4R)-3-vinyl-4-piperidinyl]-1-propanone;Chinicine;Quinotoxine;Quinotoxol;1-(6-methoxy-4-quinolyl)-3-[(3R,4R)-3-vinyl-4-piperidyl]propan-1-one;3-[(3R,4R)-3-ethenylpiperidin-4-yl]-1-(6-methoxyquinolin-4-yl)propan-1-one;d-quinotoxine;1-(6-Methoxyquinolin-4-yl)-3-((3R,4R)-3-vinylpiperidin-4-yl)propan-1-one | | CAS: | 84-55-9 | | MF: | C20H24N2O2 | | MW: | 324.42 | | EINECS: | 201-540-1 | | Product Categories: | | | Mol File: | 84-55-9.mol |  |
| | viquidil Chemical Properties |
| Melting point | 60°C | | alpha | D +43° | | Boiling point | 462.75°C (rough estimate) | | density | 1.1294 (rough estimate) | | refractive index | 1.6800 (estimate) | | storage temp. | Store at -20°C | | solubility | Chloroform (Slightly), DMSO (Slightly) | | pka | 10.13±0.10(Predicted) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | Major Application | pharmaceutical small molecule |
| | viquidil Usage And Synthesis |
| Originator | Desclidium,Spret ,France,1972 | | Uses | 1-(6-Methoxyquinolin-4-yl)-3-((3R,4R)-3-vinylpiperidin-4-yl)propan-1-one (CAS# 84-55-9) is in intermediate in the synthesis of Quinotoxine Hydrochloride (Q753500), an isomer of quinine; occurs naturally as the d-form. Present in small quantities in cinchona barks. Vasodilator (cerebral). | | Definition | ChEBI: Viquidil is a member of quinolines. | | Manufacturing Process | 2.70 g of N-benzoylhomomeroquinene ethyl ester (0.0086 mol) are mixed
with 4.0 g of ethyl quininate (0.0173 mol = 100% excess). 1.4 g of absolutely
dry pulverulent sodium ethoxide (0.0207 mol -140% excess, based on N-
benzoylhomomeroquinene ethyl ester) is added, and the reaction mixture is
heated to about 80°C with continuous stirring. As the ethyl quininate melts,
and the materials become thoroughly mixed, the initial yellow color changes
to brown and then gradually to deep red. The reaction mixture is maintained
at about 82°C for fourteen hours with continuous stirring. It is then cooled,
and the resulting very hard, dark red mass is decomposed with ice water and
benzene. The (not entirely clear) combined aqueous layers are extracted with
a small amount of ether. The clear, deep red, aqueous layer is then made just
acid to litmus. The precipitated oil is taken up in ether. Evaporation of solvent,
finally in vacuo, gives 2.56 g of a red glass. The combined benzene and ether
extracts from above, containing largely neutral material, are extracted with
10% aqueous sodium hydroxide. The alkaline extract is made just acid to
litmus, and extraction with ether followed by removal of solvent gives a
further small quantity of β-ketoester, 0.16 g.
Total weight of N-benzoylquinotoxine carboxylic acid ethyl ester thus obtained
was 2.72 g, equivalent to 63.4% of the theoretical.
2.72 g of N-benzoylquinotoxine carboxylic acid ethyl ester are dissolved in 30
cc of 1:1 aqueous hydrochloric acid (from 15 cc concentrated hydrochloric acid
and 15 cc water). The clear, reddish-orange solution is then boiled under
reflux for four hours. The very dark reddish-brown solution is extracted with
ether (from this extract 0.50 g of benzoic acid is obtained on evaporation).
The aqueous solution is then made strongly alkaline and extracted with ether.
0.23 g of ether-insoluble interface material is dissolved in benzene and set
aside. Removal of solvent from the above ether extract gives 1.39 g of crude
quinotoxine as a dark red viscous oil. | | Therapeutic Function | Vasodilator, Antiarrhythmic |
| | viquidil Preparation Products And Raw materials |
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