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| | Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) Basic information |
| Product Name: | Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) | | Synonyms: | Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI);4-Amino-2,6-difluorobenzoic acid methyl ester;4-Amino-2,6-difluorobenzoate methyl;4-Amino-2,6-difuluorobenzoic methyl ester;Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) USP/EP/BP;Methyl 4-amino-2,6-difluorobenzoate | | CAS: | 191478-99-6 | | MF: | C8H7F2NO2 | | MW: | 187.14 | | EINECS: | | | Product Categories: | AMINOACID | | Mol File: | 191478-99-6.mol |  |
| | Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) Chemical Properties |
| Boiling point | 306℃ | | density | 1.355 | | Fp | 139℃ | | storage temp. | 2-8°C(protect from light) | | pka | 0.44±0.10(Predicted) | | Appearance | Gray to brown Solid |
| RIDADR | 2811 | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 2916399090 |
| | Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) Usage And Synthesis |
| Uses | Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) can be used as an
intermediate in the synthesis of pharmaceuticals for its potential role
in the development of new drugs. | | Synthesis | Methyl 4-[(tert-butoxycarbonyl)amino]-2,6-difluorobenzoate (36 mg, 0.125 mmol) was used as a starting material and 0.5 mL of trifluoroacetic acid (TFA) was added to its solution in 1 mL of dichloromethane at room temperature. The reaction mixture was stirred for 30 minutes at room temperature. Subsequently, the reaction solution was concentrated under reduced pressure and the residue was co-evaporated with dichloromethane and toluene several times to completely remove the residual trifluoroacetic acid. Finally, the product was dried under reduced pressure. The resulting crude product, methyl 4-amino-2,6-difluorobenzoate (24 mg, quantitative yield), could be used in subsequent reactions without further purification. | | References | [1] Patent: US2016/52884, 2016, A1. Location in patent: Paragraph 0677-0680
[2] Patent: KR2015/137095, 2015, A. Location in patent: Paragraph 0902-0905 |
| | Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) Preparation Products And Raw materials |
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