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Propanamide, 2-[[[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]-, (2S)-

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Propanamide, 2-[[[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]-, (2S)- Basic information
Product Name:Propanamide, 2-[[[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]-, (2S)-
Synonyms:Propanamide, 2-[[[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]-, (2S)-;Bliretrigine;(2S)-2-[[[1-Ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]propanamide (ACI)
CAS:1233229-75-8
MF:C20H24N4O2
MW:352.43
EINECS:
Product Categories:
Mol File:1233229-75-8.mol
Propanamide, 2-[[[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]-, (2S)- Structure
Propanamide, 2-[[[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]-, (2S)- Chemical Properties
Boiling point 577.5±45.0 °C(Predicted)
density 1.22±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (141.87 mM; Need ultrasonic)
pka15.97±0.50(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Propanamide, 2-[[[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]-, (2S)- Usage And Synthesis
UsesBliretrigine is a sodium channel blocker. Bliretrigine has the effect of relieving pain[1][2][3].
References[1] WHO Drug Information, Vol. 35, No. 4, 2021. Geneva: World Health Organization; 2022.
[2] Yoshihiro OYAMADA, et al. External medicinal preparation containing N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alanineamide for treating and/or preventing peripheral neuropathic pain. Patent AU2019306705.
[3] Hironori Kinoshita, et al. Preparation of N2-[(benzimidazol-2-yl or imidazo[4,5-b]pyridin-2-yl)methyl]amino acid amide derivatives as inhibitors of sensory neuron specific sodium channel (SNS). Patent AU2009331179.
Propanamide, 2-[[[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl]amino]-, (2S)- Preparation Products And Raw materials
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