1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1)

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1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:APTO-253 HCl
CAS:1691221-67-6
Package:25mg;1520USD|50mg;1980USD|100mg;2500USD
Company Name: InvivoChem  
Tel: 13549236410
Email: sales@invivochem.cn
Products Intro: Product Name:APTO-253 HCl
CAS:1691221-67-6
Purity:98% HPLC Package:1mg Remarks:V5917
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:APTO-253 HCl
CAS:1691221-67-6
Package:1removed

1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) manufacturers

  • APTO-253 HCl
  • APTO-253 HCl pictures
  • $1520.00
  • 2026-04-21
  • CAS:1691221-67-6
  • Purity:
  • Supply Ability: 10g
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) Basic information
Product Name:1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1)
Synonyms:1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1)
CAS:1691221-67-6
MF:C22H15ClFN5
MW:403.85
EINECS:
Product Categories:
Mol File:1691221-67-6.mol
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) Structure
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) Chemical Properties
Safety Information
MSDS Information
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) Usage And Synthesis
UsesAPTO-253(LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4(KLF4)tumor suppressor. APTO-253hydrochloride exhibits antiarthritic activity[1].
References[1] Local A, et al. APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells. Mol Cancer Ther. 2018 Jun;17(6):1177-1186. [Content Brief] DOI:10.1158/1535-7163.MCT-17-1209
[2] Hongying Zhang, et al. Inhibition of c-Myc By Apto-253 As an Innovative Therapeutic Approach to Induce Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia. Blood 2016 128:1716.
[3] Haruka Tsuchiya, et al. Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis. Ann Rheum Dis. 2020 Nov2;annrheumdis-2020-218189. DOI:10.1136/annrheumdis-2020-218189
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) Preparation Products And Raw materials
Tag:1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1)(1691221-67-6) Related Product Information
LOR-253) 1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) LOR 253