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Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- Suppliers list
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| | Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- Basic information |
| Product Name: | Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- | | Synonyms: | Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)-;21-Deoxycortisol-[d8] in Methanol;D8-21-Deoxycortisol;21-Deoxycortisol (2,2,4,6,6,21,21,21-D?, 97%);21-Deoxycortisol-D8 in Methanol, Concentration: 100μg/mL (Standard) | | CAS: | 2479914-04-8 | | MF: | C21H30O4 | | MW: | 346.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2479914-04-8.mol |  |
| | Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble | | form | A crystalline solid | | color | White to off-white | | CAS Number Unlabeled | 641-77-0 |
| | Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- Usage And Synthesis |
| Uses | 21-Deoxycortisol-d8 is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia[1]. | | Biological Activity | 21-Deoxycortisol-d8 is intended for use as an internal standard for the quantification of 21-deoxycortisol by GC- or LC-MS. 21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal gland via 11-hydroxylation by 11β-hydroxylase.1,2 Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations in CYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. | | References | 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive radioimmunoassay for plasma 21-deoxycortisol to the detection of steroid-21-hydroxylase deficiencyAnn. Clin. Biochem.31(Pt. 1)56-64(1994)
2.Cristoni, S., Cuccato, D., Sciannamblo, M., et al.Analysis of 21-deoxycortisol, a marker of congenital adrenal hyperplasia, in blood by atmospheric pressure chemical ionization and electrospray ionization using multiple reaction monitoringRapid Commun. Mass Spectrom.18(1)77-82(2004) |
| | Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- Preparation Products And Raw materials |
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