D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)-

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D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)- Basic information
Product Name:D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)-
Synonyms:SGLT1/2-IN-2;D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)-
CAS:2387812-73-7
MF:C23H26F2O7
MW:452.45
EINECS:
Product Categories:
Mol File:2387812-73-7.mol
D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)- Structure
D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)- Chemical Properties
Boiling point 612.3±55.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
pka9.43±0.50(Predicted)
Safety Information
MSDS Information
D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)- Usage And Synthesis
UsesSGLT1/2-IN-2 demonstrates potent dual inhibitory activities (IC50 = 96 nM for SGLT1 and IC50 = 1.3 nM for SGLT2).
References[1] Xu G, et al. 5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127387. DOI:10.1016/j.bmcl.2020.127387
D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)- Preparation Products And Raw materials
Tag:D-xylo-Hexitol, 1,5-anhydro-4-deoxy-1-C-[5-[(3,4-dihydro-2H-1-benzopyran-6-yl)methyl]-2-hydroxy-4-methoxyphenyl]-4,4-difluoro-, (1S)-(2387812-73-7) Related Product Information
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