| Company Name: |
LGM Pharma |
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
ABAPERIDONE manufacturers
- Abaperidone
-
- $168.00
-
2026-08-30
- CAS:183849-43-6
- Purity: 99.77%
- Supply Ability: 10g
- Abaperidone
-
- $168.00
-
2026-07-14
- CAS:183849-43-6
- Purity: 99.77%
- Supply Ability: 10g
|
| | ABAPERIDONE Basic information |
| Product Name: | ABAPERIDONE | | Synonyms: | ABAPERIDONE;4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)- | | CAS: | 183849-43-6 | | MF: | C25H25FN2O5 | | MW: | 452.47 | | EINECS: | | | Product Categories: | | | Mol File: | 183849-43-6.mol |  |
| | ABAPERIDONE Chemical Properties |
| Boiling point | 667.3±55.0 °C(Predicted) | | density | 1.320±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 13.48±0.10(Predicted) |
| | ABAPERIDONE Usage And Synthesis |
| Uses | Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM. | | in vivo | The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs[1]. | | IC 50 | D2 Receptor: 17 nM (IC50); 5-HT2A Receptor: 6.2 nM (IC50) | | References | [1] Bolós J, et al. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. DOI:10.1021/jm9810396 |
| | ABAPERIDONE Preparation Products And Raw materials |
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