4-(Chloromethyl)-1H-imidazole hydrochloride manufacturers
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| | 4-(Chloromethyl)-1H-imidazole hydrochloride Basic information |
| Product Name: | 4-(Chloromethyl)-1H-imidazole hydrochloride | | Synonyms: | 5-(CHLOROMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE;4-chloromethyl-imidazolhydrochloride;4-Chloromethy-1(3)H-imidazole Hydrochlorid;4-Chloromethy-1H-imidazole Hydrochloride;1H-Imidazole, 4-(chloromethyl)-, monohydrochloride (9CI);4-(Chloromethyl)-1H-imidazole hydrochloride;1H-IMidazole, 4-(chloroMethyl)-, Monohydrochloride;1H-Imidazole, 5-(chloromethyl)-, hydrochloride (1:1) | | CAS: | 38585-61-4 | | MF: | C4H6Cl2N2 | | MW: | 153.01 | | EINECS: | | | Product Categories: | Heterocycles | | Mol File: | 38585-61-4.mol |  |
| | 4-(Chloromethyl)-1H-imidazole hydrochloride Chemical Properties |
| Melting point | 1400C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Ethanol, Methanol, Tetrahydrofuran, Toluene | | form | Solid | | color | Beige | | InChI | 1S/C4H5ClN2.ClH/c5-1-4-2-6-3-7-4;/h2-3H,1H2,(H,6,7);1H | | InChIKey | FASMXPUFMXBVRL-UHFFFAOYSA-N | | SMILES | ClCC1=CNC=N1.[H]Cl |
| Hazard Codes | Xi | | WGK Germany | WGK 3 | | HS Code | 2933299090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 | | Toxicity | mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#05103, |
| | 4-(Chloromethyl)-1H-imidazole hydrochloride Usage And Synthesis |
| Chemical Properties | Beige Solid | | Uses | 4-Chloromethyl-1H-imidazole Hydrochloride (cas# 38585-61-4) is a compound useful in organic synthesis. | | Synthesis | (A) Synthesis of 4-(chloromethyl)-1H-imidazole hydrochloride
(1) 2 mL of thionyl chloride was dissolved in 20 mL of toluene followed by the addition of 700 mg of 4-hydroxymethylimidazole hydrochloride. The reaction mixture was heated to the reflux temperature of toluene and maintained for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated to dryness under reduced pressure. 4-(Chloromethyl)-1H-imidazole hydrochloride was finally obtained as a white solid (790 mg, 99% yield). | | References | [1] Journal of Organic Chemistry, 1990, vol. 55, # 6, p. 1890 - 1901
[2] Patent: US5218115, 1993, A
[3] Journal of Organic Chemistry, 2008, vol. 73, # 21, p. 8591 - 8593
[4] Patent: US4847383, 1989, A
[5] Annales pharmaceutiques francaises, 1998, vol. 56, # 6, p. 250 - 255 |
| | 4-(Chloromethyl)-1H-imidazole hydrochloride Preparation Products And Raw materials |
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