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| | Yuanhuacine Basic information |
| Product Name: | Yuanhuacine | | Synonyms: | Yuanhuacine;gnidilatidin;(22E,24E)-12β-Benzoyloxy-22,23,24,25-tetradehydrosimplexin;Odoracin;From gnidia;Gnidia B644130K130 origin;Nsc261422;NSC 270919 | | CAS: | 60195-70-2 | | MF: | C37H44O10 | | MW: | 648.74 | | EINECS: | | | Product Categories: | | | Mol File: | 60195-70-2.mol |  |
| | Yuanhuacine Chemical Properties |
| Boiling point | 765.9±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | pka | 11.00±0.70(Predicted) | | form | Solid | | color | White to off-white | | InChIKey | CGSGRJNIABXQJQ-NSCQCFIPSA-N | | SMILES | O1[C@@]2(C(C)=C)[C@H](OC(=O)C3=CC=CC=C3)[C@@H](C)[C@@]34O[C@]1(/C=C/C=C/CCCCC)O[C@]2([H])[C@]3([H])[C@]1([H])O[C@]1(CO)[C@@H](O)[C@@]1(O)[C@@]4([H])C=C(C)C1=O |
| | Yuanhuacine Usage And Synthesis |
| Uses | Yuanhuacine (Gnidilatidin), a diterpene from Daphne genkwa, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. Yuanhuacine can induce G2/M cell cycle arrest and has broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent[1][2][3]. | | in vivo | Yuanhuacine (0.5-1 mg/kg, oral, once daily, 21 days) inhibits tumor proliferation in mice[1]. | Animal Model: | H1993 cells implanted xenograft mouse model[1] | | Dosage: | 0.5, 1 mg/kg; daily; 21 days | | Administration: | Oral | | Result: | Inhibited tumor growth by 33.4% and 38.8%, respectively, reduced tumor weight, activated AMPK, and inhibited proliferation biomarkers Ki-67 and PCNA in tumor tissues. |
| | References | [1] Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368. DOI:10.1371/journal.pone.0144368
[2] Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403. DOI:10.1074/jbc.M113.513960
[3] Charles S Fermaintt, et al. Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential. Cancers (Basel). 2021 Jun 7;13(11):2834. DOI:10.3390/cancers13112834 |
| | Yuanhuacine Preparation Products And Raw materials |
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