2-Bromo-5-fomylthiazole

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Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:2-Bromo-5-Formylthiazole
CAS:464192-28-7
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:2-bromothiazole-5-carbaldehyde
CAS:464192-28-7
Purity:0.99 Package:5G，10G，25G，50G，100G，250G,1KG
Company Name: Alchem Pharmtech,Inc.
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Products Intro: Product Name:2-Bromo-5-formylthiazole
CAS:464192-28-7
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-00949
Company Name: Wuhan Chemwish Technology Co., Ltd
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Products Intro: Product Name:2-Bromo-5-formylthiazole
CAS:464192-28-7
Purity:0.98 Package:1g;5g;25g;526g
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:2-bromo-5-fomylthiazole
CAS:464192-28-7
Purity:0.99 Package:1kg

2-Bromo-5-fomylthiazole manufacturers

  • 2-Bromo-5-fomylthiazole
  • 2-Bromo-5-fomylthiazole pictures
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:464192-28-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • 2-Bromo-5-fomylthiazole
  • 2-Bromo-5-fomylthiazole pictures
  • $15.00 / 1KG
  • 2021-07-10
  • CAS:464192-28-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • 2-Bromo-5-fomylthiazole
  • 2-Bromo-5-fomylthiazole pictures
  • $1.80 / 1KG
  • 2020-03-22
  • CAS:464192-28-7
  • Min. Order: 1g
  • Purity: 90.0%-99.9%
  • Supply Ability: 800kg
2-Bromo-5-fomylthiazole Basic information
Product Name:2-Bromo-5-fomylthiazole
Synonyms:2-BROMO-5-FORMYLTHIAZOLE;2-Bromo-1,3-thiazole-5-carboxaldehyde 98%;4-BROMOTHIAZOLE-2-CARBALDEHYDE;2-Bromo-5-fomylthiazole;2-Bromo-1,3-thiazole-5-carboxaldehyde;2-Bromo-5-formyl-1,3-thiazole;2-Bromothiazole-5-carboxaldehy;2-Bromothiazole-5-carboxaldehyde, 95%
CAS:464192-28-7
MF:C4H2BrNOS
MW:192.03
EINECS:
Product Categories:Aldehyde;Building Blocks;Thiazole;Organohalides;Aldehydes;blocks;Bromides;Thiazoles
Mol File:464192-28-7.mol
2-Bromo-5-fomylthiazole Structure
2-Bromo-5-fomylthiazole Chemical Properties
Melting point 94-96°C
Boiling point 264.9±13.0 °C(Predicted)
density 1.920±0.06 g/cm3(Predicted)
storage temp. 2-8°C
form Crystalline Powder
pka-0.94±0.10(Predicted)
color White to yellow
InChIInChI=1S/C4H2BrNOS/c5-4-6-1-3(2-7)8-4/h1-2H
InChIKeyDJUWIZUEHXRECB-UHFFFAOYSA-N
SMILESS1C(C=O)=CN=C1Br
CAS DataBase Reference464192-28-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-43-36-22
Safety Statements 26-36/37/39-36/37
WGK Germany 3
Hazard Note Irritant
HS Code 29339900
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Eye Irrit. 2
Skin Sens. 1
MSDS Information
2-Bromo-5-fomylthiazole Usage And Synthesis
Chemical PropertiesYellow powder
Uses2-Bromothiazole-5-carboxaldehyde is a reactant in the preparation of thienopyridines as potent checkpoint 1 kinase (CHK1) inhibitors.
Synthesis
2-BROMO-5-HYDROXYMETHYLTHIAZOLE

687636-93-7

2-Bromo-5-fomylthiazole

464192-28-7

General procedure for the synthesis of 2-bromo-5-formylthiazole from 2-bromothiazole-5-methanol: Manganese dioxide (3.8 g, 37.10 mmol) was added to a solution of 2-bromothiazole-5-methanol (1.44 g, 7.42 mmol) in trichloromethane (20 mL). The reaction mixture was stirred at room temperature for 3 days. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give 2-bromo-5-formylthiazole (870 mg, 61% yield) as a white solid. The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectrum (1H-NMR, 400 MHz, CDCl3): δ 9.95 (s, 1H), 8.16 (s, 1H); nuclear magnetic resonance carbon spectrum (13C-NMR, 100 MHz, CDCl3): δ 180.93, 150.47, 145.48, 142.91; mass spectra (ESI): m/z 192.31 ([MH+]).

References[1] Patent: WO2008/61795, 2008, A2. Location in patent: Page/Page column 61-62
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