- 2-Bromomalonaldehyde
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- $0.00 / 1KG
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2025-06-27
- CAS:2065-75-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
- 2-Bromomalonaldehyde
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- $70.00 / 1kg
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2025-06-03
- CAS:2065-75-0
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons
- 2-Bromomalonaldehyde
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- $0.00 / 1KG
-
2025-04-04
- CAS:2065-75-0
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
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| | 2-Bromomalonaldehyde Basic information |
| | 2-Bromomalonaldehyde Chemical Properties |
| Melting point | 132-136 °C(lit.) | | Boiling point | 134.8±25.0 °C(Predicted) | | density | 1.750±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Acetonitrile (Slightly), DMSO (Slightly) | | form | Solid | | pka | 1.70±0.10(Predicted) | | color | Pale Beige to Pale Yellow | | Sensitive | Air Sensitive | | InChI | InChI=1S/C3H3BrO2/c4-3(1-5)2-6/h1-3H | | InChIKey | SURMYNZXHKLDFO-UHFFFAOYSA-N | | SMILES | C(=O)C(Br)C=O | | CAS DataBase Reference | 2065-75-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | HS Code | 29130000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1 |
| | 2-Bromomalonaldehyde Usage And Synthesis |
| Chemical Properties | Light Yellow Solid | | Uses | Used in the formation of glyoxal-derived adducts from substituted guanines | | Synthesis | 1,1,3,3-tetramethoxypropane (23) (10 g) was used as a raw material, and a solution of water (H2O, 11 mL) with concentrated HCl (0.43 mL) was stirred at room temperature for 10 minutes. Subsequently, Br2 (3.1 mL) was slowly added dropwise to the above solution at room temperature for a controlled time of 50 minutes or more. After the dropwise addition was completed, the reaction mixture was continued to be stirred at room temperature for 20 minutes. After completion of the reaction, the mixture was concentrated under vacuum. The resulting residual solid was washed with water (H2O) to give the final target product 2-bromomalonaldehyde (24) (3.6 g, 39%) as a yellow solid. The melting point of the product was 147-148 °C; 1H NMR (CDCl3) δ 4.73-4.80 (1H,m),8.47 (2H,br s); FAB MS m/e (M-H)-149. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 1, p. 235 - 238
[2] Patent: US2005/85492, 2005, A1. Location in patent: Page/Page column 25
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 5, p. 1219 - 1233
[4] Organic and Biomolecular Chemistry, 2005, vol. 3, # 18, p. 3388 - 3398
[5] Patent: WO2004/67521, 2004, A1. Location in patent: Page 68 |
| | 2-Bromomalonaldehyde Preparation Products And Raw materials |
| Raw materials | Hydrochloric acid-->Chloroform-->Bromine-->Activated carbon-->1,1,3,3-Tetramethoxypropane | | Preparation Products | 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBALDEHYDE-->2-Bromo-5-fomylthiazole-->TERT-BUTYL 5-FORMYLTHIAZOL-2-YLCARBAMATE-->5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE-->5-bromothieno[2,3-b]pyridine-->2-Amino-5-formylthiazole-->6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE-->6-BROMO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID-->N-(5-ForMylthiazol-2-yl)acetaMide-->6-CHLOROIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE-->1-benzyl-2-methyl-1H-imidazole-carbaldehyde |
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