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[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate

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[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Basic information
Product Name:[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate
Synonyms:(Des-Gly10，D-Ala6，proethylamide9)-LRH;LHRH-A;luteinizing hormone releasing hormone (D-Ala^<6^>) analog;[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate;[D-Ala6]des-Gly10-GnRH ethylamide;[D-Ala6]des-Gly10-gonadotropin releasing hormone ethylamide;5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-NHEt;AY-25205
CAS:52435-06-0
MF:C56H78N16O12
MW:1167.32
EINECS:
Product Categories:
Mol File:52435-06-0.mol
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Structure
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Chemical Properties
density 1.48±0.1 g/cm3(Predicted)
pka9.82±0.15(Predicted)
form Solid
color White to off-white
Sequence{Pyr}-His-Trp-Ser-Tyr-{d-Ala}-Leu-Arg-Pro-NHEt
Safety Information
MSDS Information
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Usage And Synthesis
Chemical PropertiesOff-white freeze-dried powder. Soluble in water and saline.
Uses(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3].
in vivo

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (2 μg/kg; i.p.; single dose) significantly increases anxiety behavior in adult male rats with and without gonadectomy[2].
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (50 μg; single dose) improves the fertility of cows after fertilization and prevents embryo death when combined with Ainil (30 μL/kg)[3].

References[1] Wan B, et al. Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres. Int J Pharm. 2022 Sep 25;625:122032. DOI:10.1016/j.ijpharm.2022.122032
[2] Masalova OO, et al. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bull Exp Biol Med. 2019 Nov;168(1):52-54. DOI:10.1007/s10517-019-04644-4
[3] Kraevskiy A Y, et al. Surfagon and Ketaprofen for increasing fertility and preventing embryonic death in cows after insemination AY[J]. Ukrainian Journal of Ecology, 2020, 10(4): 159-164.
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Preparation Products And Raw materials
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