| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Surfagon
CAS:52435-06-0
Package:25mg/RMB 10600
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| | [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Basic information |
| Product Name: | [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate | | Synonyms: | (Des-Gly10，D-Ala6，proethylamide9)-LRH;LHRH-A;LRH-A;luteinizing hormone releasing hormone (D-Ala^<6^>) analog;[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate;[D-Ala6]des-Gly10-GnRH ethylamide;[D-Ala6]des-Gly10-gonadotropin releasing hormone ethylamide;5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-NHEt | | CAS: | 52435-06-0 | | MF: | C56H78N16O12 | | MW: | 1167.32 | | EINECS: | | | Product Categories: | | | Mol File: | 52435-06-0.mol | ![[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Structure](CAS/20180808/GIF/52435-06-0.gif) |
| | [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | form | Solid | | pka | 9.82±0.15(Predicted) | | color | White to off-white | | Sequence | {Pyr}-His-Trp-Ser-Tyr-{d-Ala}-Leu-Arg-Pro-NHEt |
| | [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Usage And Synthesis |
| Chemical Properties | Off-white freeze-dried powder. Soluble in water and saline. | | Uses | (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3]. | | in vivo | (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (2 μg/kg; i.p.; single dose) significantly increases anxiety behavior in adult male rats with and without gonadectomy[2].
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (50 μg; single dose) improves the fertility of cows after fertilization and prevents embryo death when combined with Ainil (30 μL/kg)[3].
| | References | [1] Wan B, et al. Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres. Int J Pharm. 2022 Sep 25;625:122032. DOI:10.1016/j.ijpharm.2022.122032
[2] Masalova OO, et al. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bull Exp Biol Med. 2019 Nov;168(1):52-54. DOI:10.1007/s10517-019-04644-4
[3] Kraevskiy A Y, et al. Surfagon and Ketaprofen for increasing fertility and preventing embryonic death in cows after insemination AY[J]. Ukrainian Journal of Ecology, 2020, 10(4): 159-164. |
| | [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Preparation Products And Raw materials |
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