4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)-

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Company Name: Shandong Dayou Pharmaceutical Research and Development Co., Ltd.  
Tel: hanfangpharma@126.com 15165037910
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Company Name: TargetMol Chemicals Inc.  
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Company Name: TargetMol Chemicals Inc.  
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4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- manufacturers
4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- Basic information
Product Name:4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)-
Synonyms:4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)-;Carbonic anhydrase inhibitor 7
CAS:546105-61-7
MF:C23H17N3O5S
MW:447.46
EINECS:
Product Categories:
Mol File:546105-61-7.mol
4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- Structure
4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- Chemical Properties
density 1.486±0.06 g/cm3(Predicted)
pka9.81±0.12(Predicted)
Safety Information
MSDS Information
4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- Usage And Synthesis
UsesCarbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively[1].
References[1] Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247. DOI:10.1016/j.ejmech.2022.114247
4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- Preparation Products And Raw materials
Tag:4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)-(546105-61-7) Related Product Information
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