2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide

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2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide manufacturers
2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide Basic information
Product Name:2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide
Synonyms:2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide;4-Quinolinecarboxamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-2-(3,4-dimethoxyphenyl)-;2-(3,4-dimethoxyphenyl)-N-(4-sulfamoylphenethyl)quinoline-4-carboxamide;Carbonic anhydrase inhibitor 6;RMA-305
CAS:1013213-84-7
MF:C26H25N3O5S
MW:491.56
EINECS:
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Mol File:1013213-84-7.mol
2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide Structure
2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide Chemical Properties
density 1.305±0.06 g/cm3(Predicted)
pka10.13±0.10(Predicted)
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MSDS Information
2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide Usage And Synthesis
UsesCarbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively[1].
References[1] Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247. DOI:10.1016/j.ejmech.2022.114247
2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide Preparation Products And Raw materials
Tag:2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide(1013213-84-7) Related Product Information
2-(3,4-dimethoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]quinoline-4-carboxamide 4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- Carbonic anhydrase inhibitor 5 Benzolamide Carbonic anhydrase 9 protein, mouse (HEK293, his) Carbonic Anhydrase 14 Protein, Mouse (HEK293, His)