1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) manufacturers
|
| | 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Basic information |
| Product Name: | 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) | | Synonyms: | 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI);(3R,4R)-4-aMino-1-N-Boc-3-hydroxypyrrolidine;Trans-(3R,4R)-1-Boc-3-aMino-4-hydroxypyrrolidine;rel-tert-Butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-amino-4-hydroxy-, 1,1-dimethylethyl ester, (3R,4R)-;(3R,4R)-3-Amino-1-Boc-4-hydroxypyrrolidine;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) USP/EP/BP | | CAS: | 330681-18-0 | | MF: | C9H18N2O3 | | MW: | 202.25 | | EINECS: | | | Product Categories: | AMINOACID | | Mol File: | 330681-18-0.mol |  |
| | 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Chemical Properties |
| Boiling point | 308.8±42.0 °C(Predicted) | | density | 1.179 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 14.36±0.40(Predicted) | | Appearance | White to off-white Solid |
| RIDADR | 3259 | | HazardClass | 8 | | PackingGroup | Ⅲ | | HS Code | 2933998090 |
| | 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Usage And Synthesis |
| Synthesis | General procedure for the synthesis of tert-butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate from the compound (CAS:1202067-36-4): trifluoroacetic acid (3 drops) was added to a solution of intermediate 19 (2.5 g, 8.4 mmol) in methanol (50 mL), and the reaction mixture was stirred for 2 hours. Subsequently, platinum oxide (100 mg, 0.44 mmol) was added to the reaction system and stirring was continued for 18 hours under hydrogen atmosphere. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the solvent was removed by evaporation under vacuum. The resulting crude product was purified by recrystallization from dichloromethane to afford the target product (3R,4R)-tert-butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate as a white solid (1.5 g, 89% yield). NMR hydrogen spectrum (CDCl3) data: δ 3.99 (1H, m), 3.70 (2H, m), 3.34 (2H, m), 3.12 (1H, m), 1.48 (9H, s). | | References | [1] Patent: WO2009/153554, 2009, A1. Location in patent: Page/Page column 43 |
| | 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Preparation Products And Raw materials |
|