| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
|
| | N-Acetyl-L-cysteine methyl ester Basic information |
| Product Name: | N-Acetyl-L-cysteine methyl ester | | Synonyms: | (AC-CYS-OME)2;ACETYL-L-CYSTINE DIMETHYL ESTER;AC-L-CYS-OME;3,3'-Dithiobis[(R)-2-(acetylamino)propanoic acid methyl] ester;DACDM;N,N'-Diacetylcystine dimethyl ester;N,N'-Diacetyl-L-cystine dimethyl ester;(2R)-2-(Acetylamino)-3-mercaptopropionic acid methyl ester | | CAS: | 32381-28-5 | | MF: | C12H20N2O6S2 | | MW: | 352.43 | | EINECS: | | | Product Categories: | | | Mol File: | 32381-28-5.mol |  |
| | N-Acetyl-L-cysteine methyl ester Chemical Properties |
| Melting point | 77-81 °C | | Boiling point | 584.5±50.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | DMSO: Soluble: = 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml | | pka | 13.89±0.46(Predicted) |
| | N-Acetyl-L-cysteine methyl ester Usage And Synthesis |
| Description | Dimethyl diacetyl cystinate is a derivative of the oxidized dimeric form of cysteine L-cystine (Item No. 31727).1 It inhibits UVB radiation-induced NF-κB nuclear translocation in and IL-1α secretion from HaCaT cells when used at concentrations of 50 or 100 µM. Dimethyl diacetyl cystinate (10 µg/ml) decreases proliferation and IFN-γ and IL-2 secretion in a co-culture of lymphocytes isolated from BALB/c mice and irradiated splenocytes isolated from C57BL/10J mice.2 Subconjunctival administration of dimethyl diacetyl cystinate (8 µg/animal) reduces corneal glutathione (GSH) levels and increases corneal allograft survival in mice.WARNING This product is not for human or veterinary use. | | Chemical Properties | White powder | | References | [1] MANABU KITAZAWA. Intracellular redox regulation by a cystine derivative suppresses UV-induced NF-κB activation[J]. FEBS Letters, 2002, 526 1-3: 106-110. DOI: 10.1016/s0014-5793(02)03152-6
[2] JUN YAMADA. Major histocompatibility complex semi-matching improves murine corneal allograft survival under oxidative macrophage dominancy.[J]. Transplantation, 2007, 84 7: 899-907. DOI: 10.1097/01.tp.0000284731.22247.a3 |
| | N-Acetyl-L-cysteine methyl ester Preparation Products And Raw materials |
|