- Protohypericin
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- $84.00
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2026-08-30
- CAS:548-03-8
- Purity: 98.56%
- Supply Ability: 10g
- Protohypericin
-
-
2023-02-24
- CAS:548-03-8
- Min. Order: 20mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- protohypericin
-
- $1.00
-
2020-01-13
- CAS:548-03-8
- Min. Order: 1KG
- Purity: 98%HPLC
- Supply Ability: 10 tons
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| | protohypericin Basic information |
| Product Name: | protohypericin | | Synonyms: | protohypericin;1,3,4,6,8,15-Hexahydroxy-10,13-dimethyldibenzo[a,o]perylene-7,16-dione;Dibenzo[a,o]perylene-7,16-dione, 1,3,4,6,8,15-hexahydroxy-10,13-dimethyl-;Protohypericin,naphthodianthrone,Inhibitor,NSCLC,inhibit | | CAS: | 548-03-8 | | MF: | C30H18O8 | | MW: | 506.46 | | EINECS: | | | Product Categories: | Anthraquinones, Hydroquinones and Quinones | | Mol File: | 548-03-8.mol |  |
| | protohypericin Chemical Properties |
| Boiling point | 954.3±65.0 °C(Predicted) | | density | 1.736±0.06 g/cm3(Predicted) | | solubility | DMSO: Sparingly Soluble: 1-10 mg/ml
Methanol: Sparingly Soluble: 1-10 mg/ml | | form | Solid | | pka | 5.63±0.20(Predicted) | | color | Purple to black | | LogP | 8.870 (est) |
| | protohypericin Usage And Synthesis |
| Uses | Protohypericin is a naturally occurring naphthodianthrone derived from plant Hypericum perforatum. Radioiodinated protohypericin is used in Tumor necrosis targeted radiotherapy[1][2]. | | References | [1] Baugh SF. Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure. J AOAC Int. 2005 Nov-Dec;88(6):1607-12. PMID:16526439
[2] Liu X, et al. Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model. Oncotarget. 2015 Sep 22;6(28):26400-10. DOI:10.18632/oncotarget.4568
[3] GEORGIOS PIPEROPOULOS . Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography–electrospray mass spectrometry[J]. Journal of Chromatography B: Biomedical Sciences and Applications, 1997, 695 2: Pages 309-316. DOI: 10.1016/s0378-4347(97)00188-6
[4] E M DELAEY. Photocytotoxicity of protohypericin after photoconversion to hypericin.[J]. Planta medica, 1999, 65 8: 719-722. DOI: 10.1055/s-1999-14050 |
| | protohypericin Preparation Products And Raw materials |
| Raw materials | [9,9'-Bianthracene]-10,10'(9H,9'H)-dione, 2,2',4,4',5,5'-hexahydroxy-7,7'-dimethyl--->emodin anthrone-->Emodin |
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