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| Product Name: | KP-302 | | Synonyms: | KP-302;Lucid-21-302;1H-Imidazole-1-butanamide, α-[[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino]-N-(phenylmethyl)-, (αS)- | | CAS: | 2082765-42-0 | | MF: | C20H23N5O2 | | MW: | 365.43 | | EINECS: | | | Product Categories: | | | Mol File: | 2082765-42-0.mol |  |
| | KP-302 Chemical Properties |
| Boiling point | 753.338±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.225±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 13.293±0.46(predicted) | | color | White to off-white |
| | KP-302 Usage And Synthesis |
| Uses | KP-302 (compound 23) is a selective inhibitor of protein arginine deaminase PAD2 with a Ki of 60 μM. KP-302 also reversed physical disability in the EAE mouse model of multiple sclerosis (MS) and eliminated T cell infiltration in the brain. KP-302 has the potential to be a disease-modifying agent for MS[1]. | | References | [1] Sarswat A, et al. Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis. Bioorg Med Chem. 2017 May 1;25(9):2643-2656. DOI:10.1016/j.bmc.2017.03.006 |
| | KP-302 Preparation Products And Raw materials |
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