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| Product Name: | BDW568 | | Synonyms: | BDW568;Acetic acid, 2-[(8,9-dimethylthieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-yl)thio]-, methyl ester | | CAS: | 335401-44-0 | | MF: | C12H12N4O2S2 | | MW: | 308.38 | | EINECS: | | | Product Categories: | | | Mol File: | 335401-44-0.mol |  |
| | BDW568 Chemical Properties |
| density | 1.578±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | Acetonitrile: Soluble
Chloroform: Soluble
Methanol: Soluble | | pka | -0.456±0.40(predicted) | | form | Solid | | color | White to off-white |
| | BDW568 Usage And Synthesis |
| Uses | BDW568 is a STING agonist that can selectively activate the human STINGA230 allele. BDW568 can be used to activate STINGA230-engineered macrophages in macrophage-based immunotherapy[1]. | | References | [1] Tang Z, et al. Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies[J]. ACS Medicinal Chemistry Letters, 2024.
[2] JUNXING ZHAO, JINGXIN WANG* Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform[J]. ACS Central Science, 2022, 8 10: 1424-1434. DOI: 10.1021/acscentsci.2c00609 |
| | BDW568 Preparation Products And Raw materials |
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