2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-

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2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Basic information
Product Name:2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
Synonyms:2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-;WIZ degrader 5
CAS:2879250-73-2
MF:C21H27N3O4
MW:385.46
EINECS:
Product Categories:
Mol File:2879250-73-2.mol
2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Structure
2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Chemical Properties
Boiling point 627.9±55.0 °C(predicted)
density 1.242±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka10.78±0.40(predicted)
Safety Information
MSDS Information
2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Usage And Synthesis
UsesWIZ degrader 5 (compound 41) is a WIZ degrader and induces the degradation of WIZ with maximum degradation of 88.6% in 293T cells. WIZ degrader 5 can be used for study of sickle cell disease [1].
References[1] Simone BONAZZI, et al. 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and medical uses thereof. WO2022254362A1. 2022-12-08.
2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Preparation Products And Raw materials
Tag:2,6-Piperidinedione, 3-[5-[[(3R,6S)-1-ethyl-6-methyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-(2879250-73-2) Related Product Information
6-pentadecylsalicylic acid 1H-Isoindole-1,3(2H)-dione, 5-[4-[[trans-4-[5-acetyl-3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- MOZ-IN-3 GNE-781 PU139 WM-3835