1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)-

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1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)- Suppliers list
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1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)-
Synonyms:1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)-;WIZ degrader 7
CAS:3036553-83-7
MF:C29H24N6O4
MW:520.54
EINECS:
Product Categories:
Mol File:3036553-83-7.mol
1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)- Structure
1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties
density 1.58±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka10.72±0.40(predicted)
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis
UsesWIZ degrader 7 (Example 16) is a WIZ degrader with an IC50 value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia[1].
References[1] Thomas J, et al. Compounds and their use for treatment of hemoglobinopathies. WO2024097932A1.2024-05-10.
1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 4-[[1-cyclopropyl-5-(2-methyl-4-pyridinyl)-1H-benzimidazol-6-yl]amino]-2-(2,6-dioxo-3-piperidinyl)-(3036553-83-7) Related Product Information
6-pentadecylsalicylic acid 1H-Isoindole-1,3(2H)-dione, 5-[4-[[trans-4-[5-acetyl-3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- MOZ-IN-3 GNE-781 PU139 WM-3835