4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate

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4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate manufacturers

  • UCCF-029
  • UCCF-029 pictures
  • $1980.00
  • 2026-05-11
  • CAS:2110-25-0
  • Purity:
  • Supply Ability: 10g
4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate Basic information
Product Name:4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate
Synonyms:4H-Naphtho[1,2-b]pyran-4-one, 2-(4-pyridinyl)-;UC(CF) 029;UC(CF)029;UC(CF)-029;UCCF 029;UCCF029;UCCF-029;4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate
CAS:2110-25-0
MF:C18H11NO2
MW:273.29
EINECS:
Product Categories:
Mol File:2110-25-0.mol
4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate Structure
4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate Chemical Properties
Safety Information
MSDS Information
4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate Usage And Synthesis
DescriptionUCCF-029 is a novel cystic fibrosis transmembrane conductance regulator (CFTR) activator.
UsesUCCF-029 Free base is a potent activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. UCCF-029 Free base exhibits enhanced activity through benzannulation of the flavone A-ring at the 7,8-position. UCCF-029 Free base serves as a structural guide for the development of more effective flavonoid analogues. UCCF-029 Free base demonstrates improved potency compared to apigenin in activating wild-type CFTR. UCCF-029 Free base also exhibits potential for activating the mutant CFTR (G551D-CFTR) though not as robustly as apigenin.
DefinitionChEBI: 2-pyridin-4-yl-4-benzo[h][1]benzopyranone is an organic heterotricyclic compound and an organooxygen compound.
References[1] Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain
4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate Preparation Products And Raw materials
Raw materials1'-Hydroxy-2'-acetonaphthone
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