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| | 1H-Pyrazolo[3,4-b]pyridin-3-amine Basic information |
| | 1H-Pyrazolo[3,4-b]pyridin-3-amine Chemical Properties |
| Melting point | 189-192°C | | Boiling point | 315.3±25.0 °C(Predicted) | | density | 1.61±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO, Methanol | | form | Solid | | pka | 7.17±0.20(Predicted) | | color | Yellow | | InChI | 1S/C6H6N4/c7-5-4-2-1-3-8-6(4)10-9-5/h1-3H,(H3,7,8,9,10) | | InChIKey | LUAQTQAFUORQHV-UHFFFAOYSA-N | | SMILES | Nc1n[nH]c2ncccc12 | | CAS DataBase Reference | 6752-16-5(CAS DataBase Reference) |
| Hazard Codes | Xi,T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | 2811 | | WGK Germany | 1 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 29331990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | 1H-Pyrazolo[3,4-b]pyridin-3-amine Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Synthesis | General procedure for the synthesis of 3-amino-1H-pyrazolo[3,4-b]pyridine from 2-chloro-3-cyanopyridine: 2-chloro-3-cyanopyridine (1.4 mmol) was dissolved in ethanol (10 mL) in a microwave reactor tube, followed by the addition of 5 equivalents of hydrazine hydrate (NH2NH2-H2O). The reaction mixture was placed in a microwave reactor and radiantly heated at 170 °C for 10 min. Upon completion of the reaction, the solvent was removed by rotary evaporator to afford 3-amino-1H-pyrazolo[3,4-b]pyridine in quantitative yield. | | References | [1] Patent: WO2007/59219, 2007, A1. Location in patent: Page/Page column 56
[2] Chemical Communications, 2014, vol. 50, # 85, p. 12911 - 12914
[3] Canadian Journal of Chemistry, 1988, vol. 66, # 3, p. 420-428
[4] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 4, p. 763 - 767
[5] European Journal of Medicinal Chemistry, 2013, vol. 68, p. 361 - 371 |
| | 1H-Pyrazolo[3,4-b]pyridin-3-amine Preparation Products And Raw materials |
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