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5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine

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Products Intro: Product Name:5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
CAS:1036027-54-9
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-02240
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Products Intro: Product Name:5-(trifluoromethyl)-1h-pyrrolo(2,3-b)pyridine
CAS:1036027-54-9
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Products Intro: Product Name:1H-Pyrrolo[2,3-b]pyridine, 5-(trifluoromethyl)-
CAS:1036027-54-9
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Products Intro: Product Name:1H-Pyrrolo[2,3-b]pyridine, 5-(trifluoromethyl)-
CAS:1036027-54-9
Purity:0.98 Package:1g; 5g; 10g; 25g; 100g
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Products Intro: Product Name:5-(TrifluoroMethyl)-7-azaindole
CAS:1036027-54-9

5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine manufacturers
5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Basic information
Product Name:5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine
Synonyms:1H-Pyrrolo[2,3-b]pyridine, 5-(trifluoromethyl)-;5-(TrifluoroMethyl)-7-azaindole;1H-Pyrrolo[2,3-b]pyridine, 5-(trifluoromethyl)- 5-(TrifluoroMethyl)-7-azaindole;5-TRIFLUOROMETHYL-1H-PYRROLO[2,3-B]PYRIDINE
CAS:1036027-54-9
MF:C8H5F3N2
MW:186.13
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Mol File:1036027-54-9.mol
5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Structure
5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Chemical Properties
Melting point 104-105 °C
density 1.447±0.06 g/cm3(Predicted)
storage temp. Store at room temperature
form solid
pka12.82±0.40(Predicted)
color Off-white to light brown
Safety Information
RIDADR 2811
WGK Germany 3
HazardClass 6.1
PackingGroup Ⅲ
HS Code 2933399990
MSDS Information
5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Usage And Synthesis
Synthesis A solution of 3.4 g of 5-trifluoromethyl-3-[(trimethylsilyl)ethynyl]pyridin-2-amine and 2.96 g of potassium tert-butylate in 55 cm3 of N-methylpyrrolidinone is heated at 90 ℃. for three hours. The mixture is cooled to room temperature and then poured slowly into 250 cm3 of water saturated with ammonium chloride. The mixture is diluted with ethyl acetate and filtered, separating the phases into their isomers. The aqueous phase is extracted with ethyl acetate (2*100 cm3). The organic phases are combined, dried over magnesium sulphate and concentrated under a vacuum. The residue is slowly removed in water, and the resultant suspension is filtered. The solid is dried under vacuum to obtain 1.58 g of 5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine as a brown powder.
References[1] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 117
[2] Patent: WO2008/79346, 2008, A1. Location in patent: Page/Page column 59
[3] Patent: WO2017/31325, 2017, A1. Location in patent: Paragraph 0524
[4] Patent: US2009/253679, 2009, A1. Location in patent: Page/Page column 42
5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials
Raw materials5-(Trifluoromethyl)-3-((trimethylsilyl)ethynyl)-pyridin-2-amine-->N-Methyl-2-pyrrolidone-->Potassium tert-butoxide
Tag:5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine(1036027-54-9) Related Product Information
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